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Typical clinical features include myositis, interstitial lung disease (ILD), arthritis, fever, mechanic's hands, and Raynaud's phenomenon, with a predominance in middle\u2010aged to elderly females. We report an atypical case of a 75\u2010year\u2010old male presenting with a 6\u2010month history of anorexia and fatigue, followed by a 3\u2010week progression of chest tightness and dyspnea. Initially misdiagnosed as a pulmonary infection, the patient showed no improvement after two weeks of antimicrobial therapy. Diagnosis was ultimately confirmed through bronchoscopy and detection of anti\u2013Jo\u20101 antibodies. Subsequent corticosteroid treatment led to complete radiographic resolution and significant clinical improvement. This case underscores the importance of considering ASS in elderly male patients to prevent misdiagnosis and ensure timely intervention.<\/jats:p>","DOI":"10.1002\/ccr3.72085","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:40:48Z","timestamp":1772959248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antisynthetase Syndrome Mimicking Pulmonary Infection: A Diagnostic Lesson From County\u2010Managed Hospital"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5147-3475","authenticated-orcid":false,"given":"Jufen","family":"Cheng","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital Zhejiang University School of Medicine The Second Affiliated Hospital Zhejiang University School of Medicine Kaihua Branch  Kaihua County Zhejiang Province 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