{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:56:04Z","timestamp":1774511764431,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pelvic organs prolapse (POP) is usually used to describe the pelvic organs' descent into or through the vagina. The related common complications are bleeding, extrusion, vaginal discharge, pain, and constipation; only older women and those with comorbidities seem to be most prone to persist with their use. Surgery is preferred, instead, by younger active women with advanced prolapse symptoms. The uterus lowers and slides into the vagina. Treatment varies by stage and severity. The purpose of this article was to evaluate the efficacy of LPRP in the treatment ofuterine ulcers in an old 93\u2009years' obese patient with UP stage IV non\u2010surgically treatable. Obese 93\u2010year\u2010old woman with medical history of left hip replacement, bilateral knee replacement COPD with chronic pulmonary heart disease, renal failure, chronic heart failure, one hospitalization for acute heart failure, suffering from umbilical hernia, hypertension, hyperuricemia, polyhydric arthrosis, has had a complete uterine prolapse (grade IV) for 5\u2009years. The patient has multiple vaginal ulcers as a consequence of urinary and fecal incontinence fluid in continuous contact with the occasionally inflamed everted vaginal mucosa. The ulcer area was infiltrated with L\u2010PRF membranes and covered with PRF, which were sutured and protected with an inverted glove. The results of the present case report show the positive effect of L\u2010PRF on the uterine ulcers that is a promising treatment for vaginal ulcers in case of prolapse. In conclusion, L\u2010PRF has shown significant potential as an effective treatment for chronic non\u2010healing uterine ulcers, offering advantages over conventional dressings in terms of efficacy, safety, and cost\u2010effectiveness.<\/jats:p>","DOI":"10.1002\/ccr3.72098","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:24:53Z","timestamp":1772969093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vaginal Ulcers Secondary to Stage Iv Uterine Prolapse Treated With L\u2010PRF"],"prefix":"10.1002","volume":"14","author":[{"given":"Alberta Greco","family":"Lucchina","sequence":"first","affiliation":[{"name":"Research Laboratory in Regenerative Medicine and Tissue Engineering, Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Rescigno","sequence":"additional","affiliation":[{"name":"Lavagna Hospital (Ge) ASL 4 Liguria  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canata","family":"Alessandra","sequence":"additional","affiliation":[{"name":"General practitioner Lavagna (Ge) ASL 4 Liguria  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Department, Maxillo\u2010Facial Surgery Universit\u00e0 di Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1374-6146","authenticated-orcid":false,"given":"Antonio","family":"Scarano","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine &amp; Dentistry University of Chieti\u2010Pescara  Cheti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjod.90582"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(92)91562\u2010O"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20048"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262077"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39356.604074.BE"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000424"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002\u20109378(03)00698\u20107"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0b013e31824171f9"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029\u20107844(97)00058\u20106"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.01.039"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v8.i5.202"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.105410"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192\u2010003\u20101073\u20100"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1311"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123819"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20100528.1997.tb11536.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(99)70203\u20106"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109378(96)70243\u20100"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192\u2010010\u20101286\u2010y"},{"key":"e_1_2_13_21_1","first-page":"56","article-title":"The Vaginal Profile","volume":"64","author":"Baden W. 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