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The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine, and carbamazepine are commonly implicated. Stevens\u2013Johnson syndrome due to amitriptyline combination has not been reported in the literature before.<\/jats:p>","DOI":"10.1002\/ccr3.72129","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T04:05:53Z","timestamp":1771819553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Amitriptyline Induced Life\u2010Threatening Steven\u2013Johnson Syndrome: Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2833-7179","authenticated-orcid":false,"given":"Wondwosen Mengist","family":"Dereje","sequence":"first","affiliation":[{"name":"Department of Neurology University of Gondar College of Medicine and Health Sciences  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidya","family":"Yalew","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Gondar College of Medicine and Health Sciences  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nardos","family":"Tafesse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Gondar College of Medicine and Health Sciences  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teklegiorgis Goshime","family":"Getachew","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Gondar College of Medicine and Health Sciences  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"203","article-title":"Severe Cutaneous Adverse Reactions to Drugs (SCAR): Definitions, Diagnostic Criteria, Genetic Predisposition","volume":"27","author":"Roujeau J. 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