{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:07:19Z","timestamp":1774566439265,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This case report highlights a rare occurrence of osteomalacia induced by hypophosphatemia secondary to ferric carboxymaltose (FCM) therapy in a patient with hereditary hemorrhagic telangiectasia (HHT, or Rendu\u2010Osler\u2010Weber syndrome). A 21\u2010year\u2010old man presented with left tibial pain without prior trauma, accompanied by severe hypophosphatemia, vitamin D deficiency, and elevated fibroblast growth factor 23 (FGF23) levels. Upon the full diagnostic imaging work\u2010up, F\u201018\u2010FDG PET\/CT majorly contributed to the differential diagnosis by excluding potential malignancy and verifying a stress fracture. Treatment included vitamin D supplementation and oral phosphorus replacement, along with discontinuation of ferric carboxymaltose (FCM) therapy. This case demonstrates the importance of vigilance for metabolic bone disease in patients undergoing FCM treatment, particularly those with predisposing conditions such as HHT, to prevent misdiagnosis and mitigate complications.<\/jats:p>","DOI":"10.1002\/ccr3.72134","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:42:21Z","timestamp":1771486941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Osteomalacia Following Iron Infusion Therapy in a Patient With Rendu\u2010Osler\u2010Weber Syndrome: F\u201018\u2010FDG PET\/CT Discrimination of a Stress Fracture in the Setting of a Musculoskeletal Tumor Mimic"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4572-6074","authenticated-orcid":false,"given":"Ioannis S.","family":"Vasios","sequence":"first","affiliation":[{"name":"Academic Orthopaedics Department University General Hospital of Alexandroupolis, Democritus University of Thrace  Alexandroupolis Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-6971","authenticated-orcid":false,"given":"Pipitsa N.","family":"Valsamaki","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University General Hospital of Alexandroupolis, Democritus University of Thrace  Alexandroupolis Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-2933","authenticated-orcid":false,"given":"Konstantinos","family":"Tilkeridis","sequence":"additional","affiliation":[{"name":"Academic Orthopaedics Department University General Hospital of Alexandroupolis, Democritus University of Thrace  Alexandroupolis Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-6845","authenticated-orcid":false,"given":"Savvas","family":"Deftereos","sequence":"additional","affiliation":[{"name":"Department of Radiology University General Hospital of Alexandroupolis, Democritus University of Thrace  Alexandroupolis Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3682-4303","authenticated-orcid":false,"given":"Efthymios","family":"Iliopoulos","sequence":"additional","affiliation":[{"name":"Academic Orthopaedics Department University General Hospital of Alexandroupolis, Democritus University of Thrace  Alexandroupolis Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100712"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2024.101876"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2018.03.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.12.016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.11.13.1961"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.12920"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5333.1827"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.10.1552"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0267"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziae145"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196802222780802"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01770-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2017.09.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10447"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809493"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2814"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-019-2018-7"},{"issue":"2","key":"e_1_2_12_19_1","first-page":"124","article-title":"Bone Scan in Metabolic Bone Diseases. Review","volume":"15","author":"Abdelrazek S.","year":"2012","journal-title":"Nuclear Medicine Review. Central & Eastern Europe"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015028"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.1005632"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01504608"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.8.6.519"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008465"},{"issue":"3","key":"e_1_2_12_25_1","first-page":"461","article-title":"Cellular Origin and Molecular Mechanisms of 18F\u2010FDG Uptake: Is There a Contribution of the Endothelium?","volume":"45","author":"Buck A. K.","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"issue":"3","key":"e_1_2_12_26_1","first-page":"455","article-title":"Characterization of 18F\u2010FDG Uptake in Human Endothelial Cells In\u00a0Vitro","volume":"45","author":"Maschauer S.","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.59.5.639"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.7138"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-008-0462-3"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1198-x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01792.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1923"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301264"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2529-9"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4558"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziae139"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14643"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116202"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:37:52Z","timestamp":1773005872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.72134"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72134","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72134"}}