{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:56:07Z","timestamp":1772999767651,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a 12\u2010week\u2010old pauci\u2010geste carrying twins who experienced potentially fatal hyperemesis gravidarum. Clinical and paraclinical investigations revealed severe hypovolemic shock\/dehydration, ionic disruption, undernutrition, and acute renal failure (GFR: 36.8\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    according to modified MDRD). The patient spent almost 3\u2009weeks in emergency and critical care at the University Clinics of Bukavu, where her pregnancy was tracked until her twins were born. Hyperemesis gravidarum diagnosis remains clinical, with incomplete etiopathogenesis understanding. Genetic research, including Growth Differentiation factor 15, is promising. Maternal morbidity consensus exists, but fetal effects vary by severity. Early multimodal approaches, psychological support, viral screening, Non\u2010Invasive Prenatal Testing, nutraceuticals, and long\u2010term Frozen Embryo Transfer child follow\u2010up are vital for life\u2010saving outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72135","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:42:38Z","timestamp":1771558958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Presentation and Treatment of Hyperemesis Gravidarum in a Lady Carrying Twins in the First Trimester: A Case Reports"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-5668","authenticated-orcid":false,"given":"Kesheni","family":"Banyanga David","sequence":"first","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Pediatric Department University Clinics of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmel Mbalo","family":"Walemba","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Pediatric Department University Clinics of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Ndamuso Nshombo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Department of Gynecology and Obstetrics University Clinics of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Burume","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Department of Gynecology and Obstetrics University Clinics of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bushambale Rudeha","family":"Agath","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Department of Gynecology and Obstetrics University Clinics of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Kasongo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Department of Gynecology and Obstetrics University Clinics of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germain Mugisho","family":"Matabaro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic 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Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil\u00e9mon","family":"Matabishi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Department of Gynecology and Obstetrics University Clinics of Bukavu  Bukavu Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patient Wimba","family":"Mijiriro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Official University of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Department of Gynecology and Obstetrics University Clinics of Bukavu  Bukavu Democratic Republic of Congo"},{"name":"Universite Claude Bernard de Lyon 1  Lyon 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