{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:55:21Z","timestamp":1774511721164,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Friedreich's ataxia (FA) is a rare autosomal recessive neurodegenerative disorder. Although FA is frequently associated with cardiomyopathy and diabetes mellitus, its coexistence with solid malignancies is exceptionally rare. To date, only a limited number of gastrointestinal cancers have been reported in patients with FA. This case report presents the first documented occurrence of esophageal squamous cell carcinoma (ESCC) in a genetically confirmed FA patient, highlighting the diagnostic challenges and therapeutic considerations encountered in this unique clinical setting. A 48\u2010year\u2010old Iranian man with a 29\u2010year history of Friedreich's ataxia presented with an 8\u2010month history of progressive dysphagia, recurrent hematemesis, and recent onset of complete aphagia. On examination, he was cachectic and exhibited severe alopecia, kyphoscoliosis, dysarthria, and a non\u2010ambulatory status. Laboratory evaluation demonstrated profound anemia and elevated alkaline phosphatase levels. Upper gastrointestinal endoscopy revealed a circumferential, obstructing mass in the mid\u2010esophagus, and histopathological analysis confirmed moderately differentiated ESCC. Given the patient's advanced frailty, underlying cardiomyopathy, and severe malnutrition, curative chemoradiotherapy was deemed contraindicated. Palliative management included blood transfusion, nasogastric decompression, and placement of an esophageal stent. Despite these supportive interventions, the patient experienced hemodynamic instability and progressive neurological deterioration, ultimately succumbing to disease progression.<\/jats:p>","DOI":"10.1002\/ccr3.72153","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:17:48Z","timestamp":1772961468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of Friedreich's Ataxia and Esophageal Cancer: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Alireza","family":"Mehrban","sequence":"first","affiliation":[{"name":"Clinical Department, Amol Campus of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-5268","authenticated-orcid":false,"given":"Abdolreza","family":"Babamahmoodi","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Research Center, Communicable Diseases Institute Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-1048","authenticated-orcid":false,"given":"Mohammad Taghi","family":"Hamidian","sequence":"additional","affiliation":[{"name":"Babol University of Medical Sciences  Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1842-1520","authenticated-orcid":false,"given":"Bahar","family":"Amiri","sequence":"additional","affiliation":[{"name":"Student Research Committee Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parand","family":"Ramzani","sequence":"additional","affiliation":[{"name":"Babol University of Medical Sciences  Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4388-0214","authenticated-orcid":false,"given":"Mehdi","family":"Karimi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Bogomolets National Medical University  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00175-9"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2022-0011"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06360-w"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(96)80023-0"},{"issue":"1","key":"e_1_2_17_6_1","first-page":"27","article-title":"A Case Report of a Gastric Adenocarcinoma in a Patient With Ataxia\u2010Telangiectasia","volume":"10","author":"SadeghiKhasraghi A.","year":"2012","journal-title":"Govaresh"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2021.05.01"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104606"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12303"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2025.2462357"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-017-9804-4"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51352"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_385_17"}],"container-title":["Clinical Case 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