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We retrospectively reviewed three patients with HER2\u2010positive metastatic breast cancer treated with T\u2010DXd at a tertiary hospital in Saudi Arabia who subsequently developed pneumonitis. Pneumonitis developed after 2\u20139\u2009cycles of T\u2010DXd, presenting with cough, dyspnea, and ground\u2010glass opacities. All patients received corticosteroids and required permanent discontinuation. Early recognition and multidisciplinary management of T\u2010DXd\u2010induced pneumonitis are essential. Clinicians should monitor respiratory symptoms and apply timely corticosteroid therapy.<\/jats:p>","DOI":"10.1002\/ccr3.72168","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:20:39Z","timestamp":1773015639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trastuzumab Deruxtecan\u2010Induced Pneumonitis: Case Series"],"prefix":"10.1002","volume":"14","author":[{"given":"Abeer","family":"Alhuthali","sequence":"first","affiliation":[{"name":"Clinical Pharmacy Department King Abdullah Medical City  Makkah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bushra","family":"Alqurashi","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, College of Pharmacy Umm Al\u2010Qura University  Makkah Saudi 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