{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:11:07Z","timestamp":1784545867213,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Fahr's syndrome is a rare neurological condition characterized by bilateral intracranial calcifications secondary to metabolic or endocrine abnormalities, most commonly hypoparathyroidism. This condition is distinct from Fahr's disease (primary familial brain calcification), which is genetically inherited. A 30\u2010year\u2010old South Asian Pakistani man presented with sudden\u2010onset generalized tonic\u2013clonic seizures and progressive cognitive decline. Neuroimaging revealed bilateral, symmetrical calcifications in the basal ganglia, thalami, cerebellar dentate nuclei, periventricular regions, and centrum semiovale. Laboratory evaluation revealed severe hypocalcemia, hypomagnesemia, and markedly reduced parathyroid hormone levels, consistent with hypoparathyroidism. The patient was treated with calcium supplementation, calcitriol, vitamin D, magnesium replacement, and antiepileptic therapy, resulting in clinical stabilization of the patient. Fahr's syndrome should be considered in young patients presenting with seizures and cognitive impairment when characteristic intracranial calcifications are identified. Early recognition and correction of metabolic abnormalities can improve the outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.72206","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:32:52Z","timestamp":1773297172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fahr's Syndrome in a Young Adult Male: A Case of Seizure and Cognitive Decline Secondary to Hypoparathyroidism"],"prefix":"10.1002","volume":"14","author":[{"given":"Sarah","family":"Nisar","sequence":"first","affiliation":[{"name":"Khyber Teaching Hospital  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Sebring Advent Health  Sebring Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Haris","family":"Khan","sequence":"additional","affiliation":[{"name":"Saidu Medical College  Swat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8861-0367","authenticated-orcid":false,"given":"Fatima","family":"Sajjad","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Afridi","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaryab","family":"Bacha","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibi","family":"Hafza","sequence":"additional","affiliation":[{"name":"Khyber Medical College  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8208-0689","authenticated-orcid":false,"given":"Kamil Ahmad","family":"Kamil","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Mirwais Regional Hospital  Kandahar Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-156"},{"issue":"6","key":"e_1_2_12_3_1","first-page":"515","article-title":"Asymptomatic Familial Basal Ganglia Calcification With Autosomal Dominant Inheritance: A Family Report","volume":"32","author":"Yamada N.","year":"2000","journal-title":"No to Hattatsu=Brain and Development"},{"key":"e_1_2_12_4_1","first-page":"129","article-title":"Verkalkung der Hirngefasse","volume":"50","author":"Fahr T. V.","year":"1930","journal-title":"Zentralblatt f\u00fcr Allgemeine Pathologie Und Pathologische Anatomie"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3329\/bmjk.v45i1-2.13628"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/302558"},{"issue":"7","key":"e_1_2_12_7_1","first-page":"45","article-title":"Fahr's Disease or Fahr's Syndrome?","volume":"13","author":"Perugula M. L.","year":"2016","journal-title":"Innovations in Clinical Neuroscience"},{"key":"e_1_2_12_8_1","unstructured":"P. B.Manyam \u201cBilateral Striopallidodentate Calcinosis Orphanet: Orphanet \u201d(2010)."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1049"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.3.350"},{"issue":"2","key":"e_1_2_12_11_1","article-title":"Recurrent Seizures in an Adolescent Female With Extensive Intracranial Calcifications: A Case Report of Fahr's Syndrome Secondary to Hypoparathyroidism","volume":"17","author":"Mohammed Y. E.","year":"2025","journal-title":"Cureus"},{"issue":"17","key":"e_1_2_12_12_1","first-page":"592","article-title":"Hipoparatireoidismo e S\u00edndrome de Fahr: S\u00e9rie de Casos","volume":"44","author":"Arruda A. 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G.","year":"2022","journal-title":"Clinical Neuropsychiatry"},{"issue":"10","key":"e_1_2_12_14_1","article-title":"Psychiatric Manifestations in Fahr's Syndrome: A Case Report","volume":"12","author":"Kumar P.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/11795476231178119"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.349669"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.08.2009.2216"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515985"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001032"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038542"},{"key":"e_1_2_12_21_1","unstructured":"F. 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