{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:02:15Z","timestamp":1793037735492,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Somatic malignant transformation (SMT) in germ cell tumors (GCTs) is a rare but clinically significant event. Among non\u2010seminomatous germ cell tumors (NSGCTs), teratomas can undergo malignant transformation, with neuroblastoma\u2010like differentiation being exceptionally rare. No standardized treatment protocols exist, and management is typically extrapolated from conventional approaches for GCTs and neuroblastoma. We report the first documented case of neuroblastoma arising within a testicular teratoma in a 25\u2010year\u2010old male presenting with a painless right testicular mass. Serum tumor markers showed elevated beta\u2010hCG, while AFP and LDH were normal. Imaging revealed no metastases. Radical orchiectomy was performed, and histopathology confirmed a mixed NSGCT with teratomatous and minor embryonal carcinoma components, with immunohistochemistry confirming neuroblastoma differentiation. The tumor was staged as pT1 (AJCC 8th edition). The patient completed four cycles of chemotherapy and remains in complete remission. Neuroblastoma arising within a testicular teratoma is an exceptionally rare occurrence, posing diagnostic and therapeutic challenges. Early diagnosis, histopathological evaluation, and multidisciplinary management are crucial for optimal outcomes. Further research is needed to refine treatment strategies for such rare malignancies.<\/jats:p>","DOI":"10.1002\/ccr3.72216","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:29:04Z","timestamp":1773005344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First Case of Neuroblastoma\u2010Like Somatic\u2010Type Malignancy Arising in the Teratomatous Component of a Mixed Non\u2010Seminomatous Testicular Germ Cell Tumor in an Adult"],"prefix":"10.1002","volume":"14","author":[{"given":"Karl","family":"Ziade","sequence":"first","affiliation":[{"name":"MEDICA Research Investigation  Hadath Lebanon"},{"name":"Faculty of Medical Sciences Saint Joseph University  Achrafieh Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-392X","authenticated-orcid":false,"given":"Jana","family":"Kotaich","sequence":"additional","affiliation":[{"name":"MEDICA Research Investigation  Hadath Lebanon"},{"name":"Faculty of Medical Sciences Lebanese University  Hadath Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Assaf","sequence":"additional","affiliation":[{"name":"Notre Dame Des Secours University Hospital Center  Byblos Lebanon"},{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Aftimos","sequence":"additional","affiliation":[{"name":"Institut National de Pathologie  Beirut Lebanon"},{"name":"Chu Notre\u2010Dame Des Secours  Jbeil Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adib","family":"Ziade","sequence":"additional","affiliation":[{"name":"H\u00f4pital Fran\u00e7ais du Levant  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14667"},{"issue":"4","key":"e_1_2_14_3_1","first-page":"179","article-title":"Management of Testicular Germ Cell Tumors","volume":"21","author":"Wee C. E.","year":"2023","journal-title":"Clinical Advances in Hematology & Oncology: HO"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.5644\/ama2006\u2010124.326"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20859"},{"issue":"3","key":"e_1_2_14_6_1","first-page":"145","article-title":"Germ Cell Tumours","volume":"5","author":"Talerman A.","year":"1985","journal-title":"Annales de Pathologie"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-1267-AOOTGC"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896910390680"},{"key":"e_1_2_14_9_1","unstructured":"\u201cTypes of Testicular Cancer \u201d(2024) https:\/\/www.hopkinsmedicine.org\/health\/conditions\u2010and\u2010diseases\/testicular\u2010cancer\/types\u2010of\u2010testicular\u2010cancer."},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/10935266221129087"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00141-4"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/pm.2018.77304"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1998.tb00057.x"},{"issue":"11","key":"e_1_2_14_14_1","first-page":"FD14","article-title":"Collision Tumours of Ovary: A Very Rare Case Series","volume":"8","author":"Singh A. K.","year":"2014","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"key":"e_1_2_14_15_1","unstructured":"\u201cTwo Cases of Primary Ovarian Neuroblastoma Arising From Mature Cystic Teratomas\u2014PMC \u201d(2025) https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3862328\/."},{"key":"e_1_2_14_16_1","unstructured":"\u201cPrimary Ovarian Neuroblastoma\u2014PubMed \u201d(2025) https:\/\/pubmed.ncbi.nlm.nih.gov\/20371194\/."}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:07:58Z","timestamp":1774505278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.72216"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72216","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72216"}}