{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:53:37Z","timestamp":1774511617217,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Anti\u2010synthetase syndrome (ASS) is a rare autoimmune disorder of idiopathic inflammatory myopathy spectrum, characterized by the presence of aminoacyl\u2010tRNA synthetase antibodies, most commonly anti\u2010Jo\u20101. Clinically presents with interstitial lung disease (ILD), myositis, and arthritis, and may be confused with other autoimmune conditions such as polymyositis (PM), dermatomyositis (DM), and Sj\u00f6gren's syndrome. We present a 41\u2010year\u2010old French\u2010Moroccan woman with progressive dyspnea, dry cough, weight loss, and diffuse myalgia. Extensive autoimmune and laboratory investigations revealed positive anti\u2010histidyl\u2010transfer RNA synthetase (anti\u2010Jo\u20101), anti\u2010Ro52, and anti\u2010cyclic citrullinated peptide (anti\u2010CCP) antibodies, with elevated creatine phosphokinase (CPK) and lactate dehydrogenase (LDH). Electromyography (EMG) and magnetic resonance imaging (MRI) supported myositis, while chest computed tomography (CT) showed ground\u2010glass opacities and reticulations consistent with fibrosing interstitial lung disease (ILD). She was diagnosed with anti\u2010synthetase syndrome (ASS)\u2010associated ILD. High\u2010dose corticosteroids, cyclophosphamide, and later tacrolimus, alongside supportive care, were provided, which resulted in significant pulmonary function improvement (forced vital capacity [FVC] 56%\u201392%, diffusing capacity for carbon monoxide [DLCO] 32%\u201370%) with preserved exercise tolerance. Our case report illustrates the importance of considering ASS in patients with unexplained ILD and myositis. Prompt recognition and combined immunosuppressive therapy can achieve substantial functional recovery and prevent long\u2010term respiratory compromise.<\/jats:p>","DOI":"10.1002\/ccr3.72242","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:05:16Z","timestamp":1773637516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Non\u2010Specific Interstitial Pneumonia<\/i>\n                    in Anti\u2010Jo1 Synthetase Syndrome With Probable Gougerot Syndrome: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-1977","authenticated-orcid":false,"given":"Ali","family":"Gohar","sequence":"first","affiliation":[{"name":"Lahore General Hospital  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozaire","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Pneumology Clinic  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruman","family":"Shahzad","sequence":"additional","affiliation":[{"name":"Pakistan Kidney and Liver Institute and Research Center  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College  Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4885-0410","authenticated-orcid":false,"given":"Abdul Rehman Shahid","family":"Khan","sequence":"additional","affiliation":[{"name":"Lahore General Hospital  Lahore Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1750-3278","authenticated-orcid":false,"given":"Hamad","family":"Qayyum","sequence":"additional","affiliation":[{"name":"Health and Population Department, Government of Punjab  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joham","family":"Ajmal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College  Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5248-0749","authenticated-orcid":false,"given":"Muhammad Husnain","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tentishev Satkynbai Memorial Asian Medical Institute  Kant Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.03.011"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230802"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00026703"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/japt.japt_3_21"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.022"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1297\u2010319X(03)00012\u20105"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600623791"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001422"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead481"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CPM.0000000000000171"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10794"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.50012"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197601000-00005"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010020\u201001388\u20100"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/16872.7361"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010019\u20102146\u20100"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010023\u201004040\u20107"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.14740\/jmc4031"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:04:58Z","timestamp":1774505098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.72242"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72242","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72242"}}