{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:53:54Z","timestamp":1774511634878,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lymphangioma is a congenital malformation of the lymphatic system, commonly affecting the head and neck region. Macroglossia due to lymphangioma in adolescence is uncommon, making this case noteworthy. This condition can affect oral function, speech, and quality of life, making early diagnosis and intervention essential. This report highlights a 14\u2010year\u2010old Balouch female presenting with progressive tongue enlargement beginning at age five. Intraoral examination revealed an enlarged tongue with a pebbly surface, particularly involving the ventral side of the tongue, without osseous involvement on radiographs. Differential diagnoses included hemangioma and lymphangiomegaly; however, histopathological analysis confirmed lymphangioma. The patient underwent sclerotherapy, resulting in a significant reduction in tongue size, improved oral function, and resolution of related symptoms. Follow\u2010up revealed no recurrence or major complications. Early recognition and appropriate management of lymphangioma\u2010induced macroglossia are essential to prevent functional limitations and improve quality of life. While surgical excision remains the conventional treatment, sclerotherapy offers a less invasive, effective alternative with lower morbidity. This case contributes to the limited literature on adolescent\u2010onset oral lymphangioma and underscores the value of a multidisciplinary approach in ensuring optimal outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.72249","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:18:43Z","timestamp":1773375523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphangioma\u2010Induced Macroglossia in an Adolescent: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7762-372X","authenticated-orcid":false,"given":"Arezoo","family":"Heidary","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Faculty of Dentistry Yazd Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-9111","authenticated-orcid":false,"given":"Mojtaba","family":"Mehrabanian","sequence":"additional","affiliation":[{"name":"Dental Research Center, Dental Research Institute, School of Dentistry Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.10.012"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2024.04.095"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90062-8"},{"issue":"3","key":"e_1_2_14_5_1","first-page":"352","article-title":"Oral Lymphangioma: Case Report","volume":"8","author":"Vasconcelos M. G.","year":"2011","journal-title":"RSBO. Revista Sul\u2010Brasileira de Odontologia"},{"issue":"1","key":"e_1_2_14_6_1","first-page":"108","article-title":"Oral Lymphangiomas: Clinical and Histopathological Relations","volume":"22","author":"Kolay S. K.","year":"2018","journal-title":"Journal of Oral and Maxillofacial Pathology: JOMFP"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.169851"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-02411-4"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2023.12.532"},{"issue":"9","key":"e_1_2_14_10_1","article-title":"Lymphangioma Circumscriptum on the Buccal Mucosa: A Case Report of a Rare Entity","volume":"16","author":"Venkatesha R. R.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-024-04603-0"},{"issue":"2","key":"e_1_2_14_12_1","first-page":"699","article-title":"Coincidence of Large Lingual Lymphangioma and Geographic Tongue: A Case Report and Literature Review","volume":"48","author":"Owlia F.","year":"2024","journal-title":"Journal of Mashhad Dental School"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7890338"},{"issue":"1","key":"e_1_2_14_14_1","first-page":"1","article-title":"Lymphangiohemangioma of Buccal Mucosa: Report of a Rare Case","volume":"46","author":"Yarmand F.","year":"2015","journal-title":"Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-5950.85862"},{"issue":"4","key":"e_1_2_14_16_1","first-page":"311","article-title":"Lymphangioma of the Tongue Associated With Open Bite: Case Report","volume":"20","author":"Farronato M.","year":"2019","journal-title":"European Journal of Paediatric Dentistry"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01108-z"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:05:14Z","timestamp":1774505114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.72249"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72249","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72249"}}