{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:55:43Z","timestamp":1774511743617,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Large cyst\u2010like periapical radiolucencies with cortical perforations are traditionally managed surgically. However, nonsurgical retreatment may be effective when adequate disinfection and seal are achieved. This case report describes the management of a large maxillary periapical lesion involving five endodontically treated teeth (from 21 to 25), associated with buccal and palatal cortical perforations and maxillary sinus involvement. Nonsurgical retreatment using enhanced disinfection and obturation with a hydraulic calcium\u2010silicate sealer was performed. Successfully establishing patency was reflected in the creation of evident sealer puffs. Radiographic follow\u2010up at 8\u2009months and 2\u2009years using Cone\u2010Beam Computed Tomography (CBCT) demonstrated substantial bone fill and near\u2010complete re\u2010establishment of both cortical plates. The patient remained asymptomatic throughout the follow\u2010up period. This case illustrates that, when meticulously executed and supported by modern bioactive materials, nonsurgical retreatment can promote significant healing even in extensive lesions, although surgical intervention remains the recommended secondary option when indicated.<\/jats:p>","DOI":"10.1002\/ccr3.72260","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:40:53Z","timestamp":1773114053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nonsurgical Endodontic Retreatment of a Large Cyst\u2010Like Periapical Lesion With Buccal and Palatal Cortical Plate Perforations and Maxillary Sinus Involvement: A 2\u2010Year\n                    <scp>CBCT<\/scp>\n                    Follow\u2010Up Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Mohamed Ahmed","family":"Elsayed","sequence":"first","affiliation":[{"name":"Department of Endodontics RAK College of Dental Sciences, RAK Medical and Health Sciences University  Ras Al\u2010Khaimah UAE"},{"name":"Department of Endodontics, Faculty of Dentistry Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawar Naguib","family":"Nawar","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry British University in Egypt  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-9695","authenticated-orcid":false,"given":"Mohmed Isaqali","family":"Karobari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University  Chennai Tamil Nadu India"},{"name":"Department of Restorative Dentistry &amp; Endodontics, Faculty of Dentistry University of Puthisastra  Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.07.027"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13783"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1299"},{"key":"e_1_2_14_5_1","article-title":"Conservative Approach in Managing Complex Odontogenic Lesions: A Case Report and Literature Review","volume":"16","author":"Vijayashree R. 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