{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:20:58Z","timestamp":1778275258636,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Metronidazole is a commonly used antibiotic with a good safety and economic profile, but it may rarely be neurotoxic, causing peripheral neuropathy and encephalopathy. Most literature suggests that prolonged drug therapy, that is, a duration of &gt;\u20094\u2009weeks and a dosage of &gt;\u200942\u2009g, is associated with neurotoxicity, though the exact dose\u2010dependent drug's relationship with neurotoxicity has not been discovered yet. We herein describe a case of a 41\u2010year\u2010old male diagnosed with a liver abscess and treated with a cumulative dose of 12\u2009g of metronidazole before the onset of peripheral neuropathy. Peripheral neuropathy worsened due to the continuation of the same treatment. The possibility of metronidazole\u2010induced peripheral neuropathy was suspected after ruling out all the other causes. NCS suggested multiple sensorimotor demyelinating polyneuropathy in all four limbs, contrasting with most of the literature, which mentioned axonal degeneration in the case of metronidazole toxicity, but in line with some literature that has mentioned demyelination as the suspected mechanism. However, the exact mechanism of toxicity is yet to be uncovered. Improvement was noted within 5\u2009days of stopping the drug, which further confirmed the diagnosis.<\/jats:p>","DOI":"10.1002\/ccr3.72266","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:00:15Z","timestamp":1773288015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peripheral Neuropathy Induced by a Short Course of Metronidazole: A Case Report of Diagnostic Challenge"],"prefix":"10.1002","volume":"14","author":[{"given":"Sonam","family":"Dhenga","sequence":"first","affiliation":[{"name":"Maharajgunj Medical Campus Institute of Medicine, Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4723-6045","authenticated-orcid":false,"given":"Milan","family":"Pokhrel","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus Institute of Medicine, Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simran","family":"Rauniyar","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus Institute of Medicine, Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5649-625X","authenticated-orcid":false,"given":"Kundan Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus Institute of Medicine, Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sony","family":"K.C.","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus Institute of Medicine, Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sugam Ale","family":"Magar","sequence":"additional","affiliation":[{"name":"Nepal Medical College, Kathmandu University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","article-title":"Metronidazole\u2010Induced Cerebellar Toxicity","volume":"8","author":"Agarwal A.","year":"2016","journal-title":"Neurol Int [Internet]"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002400103"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"397","article-title":"Therapeutic Uses of Metronidazole and Its Side Effects: An Update","volume":"23","author":"Hern\u00e1ndez Ceruelos A.","year":"2019","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.08.033"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa395"},{"issue":"10","key":"e_1_2_11_7_1","article-title":"Metronidazole and Peripheral Neuropathy: A Report of Two Cases of (Unusual) Side Effects","volume":"14","author":"Gussago S.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5348\/101402Z01MN2023CR"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-223463"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9123-1"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"291","article-title":"Metronidazole Neuropathy: A Case Report","volume":"42","author":"Takeuchi H.","year":"1988","journal-title":"Japanese Journal of Psychiatry and Neurology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)60872-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90577-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738060210051201"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.310097"}],"container-title":["Clinical Case 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