{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:55:42Z","timestamp":1780059342652,"version":"3.54.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vincristine is a cornerstone chemotherapeutic agent in combination regimens for lymphoid malignancies; however, its neurotoxicity remains a major dose\u2010limiting adverse effect. While vincristine\u2010induced peripheral neuropathy (VIPN) commonly presents as a symmetric, sensory\u2010predominant polyneuropathy, isolated unilateral motor neuropathy causing foot drop is exceedingly rare. We report a case of a 64\u2010year\u2010old male with extranodal diffuse large B\u2010cell lymphoma (DLBCL) of the left calf muscle, staged as Ann Arbor stage IE with Revised International Prognostic Index (R\u2010IPI) score of 2, who developed left\u2010sided foot drop following the second cycle of dose\u2010adjusted R\u2010DA\u2010EPOCH chemotherapy. Neurological examination confirmed isolated left peroneal nerve palsy with mild sensory involvement, and nerve conduction studies revealed motor axonal neuropathy consistent with vincristine toxicity. MRI excluded local compressive or infiltrative pathology and demonstrated interval tumor response. Vincristine dosing did not exceed the capped dose of 2\u2009mg during the first two cycles; from the third cycle onward, the dose was reduced by approximately 60%. Early physiotherapy, ankle\u2010foot orthosis support, and symptomatic pharmacologic therapy were initiated, leading to gradual neurological recovery. This case highlights the importance of early recognition of vincristine\u2010induced neuropathy and timely dose adjustment to prevent irreversible deficits while maintaining therapeutic efficacy.<\/jats:p>","DOI":"10.1002\/ccr3.72283","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:11:16Z","timestamp":1773637876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vincristine\u2010Induced Unilateral Foot Drop in a Patient With Diffuse Large B\u2010Cell Lymphoma: A Rare Presentation of Severe Motor Axonopathy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4965-1246","authenticated-orcid":false,"given":"Nishchal","family":"Regmi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Patan Academy of Health Sciences  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Pant","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Patan Academy of Health Sciences  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umang","family":"Gupta","sequence":"additional","affiliation":[{"name":"Palisades Medical Center Hackensack Meridian Health  North Bergen New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mipsang","family":"Lama","sequence":"additional","affiliation":[{"name":"Department of Hematology Patan Academy of Health Sciences  Lalitpur 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