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We report a case of a 48\u2010year\u2010old female who presented with fever, dyspnea, and pleuritic chest pain. High\u2010resolution computed tomography of the chest revealed bilateral pleural effusions. Autoimmune serologic testing showed strongly positive antinuclear antibody and anti\u2010double\u2010stranded DNA antibodies. After exclusion of infectious and alternative autoimmune etiologies, a diagnosis of acute lupus pneumonitis was made. The patient showed marked clinical improvement following systemic corticosteroid therapy. This case emphasizes the importance of early recognition and prompt immunosuppressive treatment to improve clinical outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.72314","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:10:38Z","timestamp":1773911438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Lupus Pneumonitis: An Uncommon Initial Presentation of Systemic Lupus Erythematosus\u2014A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9999-7112","authenticated-orcid":false,"given":"Raj","family":"Adhikari","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kathmandu Medical College and Teaching Hospital  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabin","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kathmandu Medical College and Teaching Hospital  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine King Edward Medical University  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X211040696"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20101685537"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.2.159"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102020\u2010234638"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2010.11.004"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314555171"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12473"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7389"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316646461"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010214819"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529\u20100131(200102)44:2<376::AID\u2010ANR56>3.0.CO;2\u20102"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.4.1171"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20102113.99115"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:08:20Z","timestamp":1774505300000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.72314"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72314","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72314"}}