{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:56:57Z","timestamp":1774511817316,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Biphasic pulmonary blastoma is a rare lung malignancy, accounting for less than 0.5% of all primary lung tumors. It is characterized by a biphasic nature of those tumors that consist of an admixture of epithelial and mesenchymal components. Up to this date, no standardized treatment approach has been developed and patient's prognosis remains poor. We present the case of an 85\u2009year\u2010old female who presented with dyspnea, associated with cough and hemoptysis, that has rapidly evolved over the past weeks, along with severe weight loss and anorexia. The patient was ultimately diagnosed with biphasic pulmonary blastoma on a liver core biopsy. To the best of our knowledge, this is the first case of biphasic pulmonary blastoma to be reported in Lebanon. The aggressive biological behavior of this rare tumor is highlighted by the occurrence of liver metastasis early on. It underlines the importance of recognizing this entity, even in metastatic sites. Death occurring within days of biopsy illustrates the fulminant course of those malignancies and its capacity to outpace routine diagnostic evaluation.<\/jats:p>","DOI":"10.1002\/ccr3.72325","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:07:41Z","timestamp":1773911261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biphasic Pulmonary Blastoma: A Rare Tumor With Fatal Outcome\u2014First Reported Case From Lebanon"],"prefix":"10.1002","volume":"14","author":[{"given":"Houssein","family":"Chahrour","sequence":"first","affiliation":[{"name":"School of Medicine University College Cork  Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Nammour","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Sciences Holy Spirit University of Kaslik  Jounieh Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3038-4537","authenticated-orcid":false,"given":"Joseph A.","family":"Akiki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Saint Joseph University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad H.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Lebanese University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9677-4108","authenticated-orcid":false,"given":"Wassim","family":"Hamadeh","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Lebanese University  Beirut Lebanon"},{"name":"National Institute of Public Health Clinical Epidemiology and Toxicology\u2013Lebanon (INSPECT\u2010LB)  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.03.018"},{"key":"e_1_2_13_3_1","first-page":"193","article-title":"Pulmonary Blastomatoid Carcinosarcoma: Clinicopathologic and Genomic Features","volume":"54","author":"Lee H.","year":"2020","journal-title":"Journal of Pathology and Translational Medicine"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107916"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13701"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3941\/jrcr.v11i9.3153"},{"key":"e_1_2_13_7_1","volume-title":"WHO Classification of Tumours of the Lung","author":"Travis W. D.","year":"2021"},{"key":"e_1_2_13_8_1","first-page":"45","article-title":"Diagnostic Utility of TTF\u20101 and p40 in Lung Carcinoma","volume":"12","author":"Zhang L.","year":"2023","journal-title":"Journal of Medical Sciences and Health"},{"key":"e_1_2_13_9_1","unstructured":"\u201cBiphasic Tumors of the Lung \u201dThoracic Key https:\/\/thoracickey.com\/biphasic\u2010tumors\u2010of\u2010the\u2010lung\/#:~:text=Primary%20malignant%20biphasic%20tumors%20occurring group%20are%20blastomas%20and%20carcinosarcomas."},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00172\u20102016"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800968"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.900501"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000068"},{"issue":"1","key":"e_1_2_13_14_1","first-page":"983","article-title":"Classic Biphasic Pulmonary Blastoma With Brain and Axillary Metastases: A Case Report With Molecular Analysis and Review of Literature","volume":"8","author":"Xiu Y.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174334"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2021.101556"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9784"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20100500\u20107\u2010294"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:08:11Z","timestamp":1774505291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.72325"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72325","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72325"}}