{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:32Z","timestamp":1753862852191,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"Key Clinical Message<\/jats:title>AL patients develop the unique toxicities of fluid retention and non\u2010cardiogenic pulmonary edema during the course of stem cell mobilization. We propose mobilization with CART as effective and safe treatment for AL patients with refractory anasarca.<\/jats:p><\/jats:sec>Abstract<\/jats:title>We describe a 63\u2010year\u2010old male with systemic immunoglobulin light chain (AL) amyloidosis with cardiac, renal, and liver involvement. After four courses of CyBorD, mobilization with G\u2010CSF at 10\u2009\u03bcg\/kg was initiated and CART was simultaneously performed for fluid retention. No adverse events were observed during collection or reinfusion. Anasarca gradually disappeared and he underwent autologous hematopoietic stem cell transplantation. The complete remission of AL amyloidosis has been maintained, and the condition of the patient has remained stable for 7\u2009years. We propose mobilization with CART as an effective and safe treatment option for AL patients with refractory anasarca.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7233","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T05:06:43Z","timestamp":1683695203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of systemic AL<\/scp> amyloidosis with autologous hematopoietic stem cell transplantation combined with cell\u2010free and concentrated ascites reinfusion therapy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-9759","authenticated-orcid":false,"given":"Satoko","family":"Oka","sequence":"first","affiliation":[{"name":"Division of Hematology Japanese Red Cross Society Wakayama Medical Center Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Pathology Japanese Red Cross Society Wakayama Medical Center Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/91.2.141"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01208-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00772.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2005.08.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.524329"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-099481"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.14.3350"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-390930"},{"key":"e_1_2_8_10_1","unstructured":"JohnstonPB LacyMQ DispenzieriA et al.Toxicities associated with stem cell mobilization utilizing cyclophosphamide and growth factor versus G\u2010CSF alone in primary systemic amyloidosis.2000."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1206"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177303"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.08.018"},{"key":"e_1_2_8_14_1","first-page":"20","article-title":"Spontaneous resolution of refractory ascites in the late phase after cord blood transplantation in acute myeloid leukemia","volume":"62","author":"Kawamura T","year":"2021","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_8_15_1","first-page":"130","article-title":"Refractory ascites developing in late\u2010phase of cord blood transplantation improving with CART","volume":"60","author":"Hiroi T","year":"2019","journal-title":"Rinsho Ketsueki"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T08:44:42Z","timestamp":1692434682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/ccr3.7233"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7233","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2023-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7233"}}