{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:56:40Z","timestamp":1774511800761,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Central venous catheters (CVCs) are crucial in critical care but may occasionally lead to rare, serious complications such as vascular erosion and extravasation of infused solutions. Leakage of total parenteral nutrition (TPN) into the pleural space can mimic chylothorax, potentially delaying correct diagnosis and appropriate treatment. An 83\u2010year\u2010old male with COVID\u201019\u2010related acute respiratory distress syndrome (ARDS) received TPN via a left\u2010sided CVC, which remained in a suboptimal position for 18\u2009days. On day 18, he developed sudden respiratory deterioration associated with bilateral milky pleural effusions. Initially misdiagnosed as chylothorax, subsequent pleural fluid analysis revealed elevated glucose and triglyceride levels. Computed tomography demonstrated vascular erosion near the junction of the brachiocephalic vein and superior vena cava. The CVC was subsequently removed, enteral nutrition initiated, and the pleural effusions resolved. However, the patient eventually succumbed to progressive ARDS. This case highlights the risk of delayed vascular erosion associated with suboptimally positioned CVCs, highlighting the diagnostic difficulty posed by TPN extravasation mimicking chylothorax. Prompt recognition of this complication is crucial to prevent adverse outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.72336","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:11:27Z","timestamp":1773918687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Central Venous Catheter\u2010Related Extravasation Due to Delayed Vascular Erosion"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-2630","authenticated-orcid":false,"given":"Yong Chae","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Chungnam National University Hospital  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-597X","authenticated-orcid":false,"given":"Jun Wan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Chungnam National University Hospital  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.8232"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/nan.0000000000000532"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198904000\u201000014"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2005.05.011"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010197903000\u201000021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024\u2010019\u201000113\u20106"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medine.2024.05.004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607191015005513"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1633"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010006\u20100507\u20109"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/320001"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.05.024"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.03.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.08.010"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2022.101623"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.3.820"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057x8801600317"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115574000"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000330"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/11297298251336809"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/11297298251347084"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72336","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:07:54Z","timestamp":1774505274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.72336"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72336","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72336"}}