{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:56:44Z","timestamp":1774511804592,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hypertension is common in autosomal\u2010dominant polycystic kidney disease (ADPKD) but may occasionally reflect a secondary etiology. We report a 71\u2010year\u2010old man with ADPKD and end\u2010stage renal disease who developed persistent, refractory hypertension following renal transplantation despite multidrug therapy and bilateral native nephrectomy. Evaluation revealed an elevated aldosterone\u2010to\u2010renin ratio, and adrenal venous sampling confirmed unilateral aldosterone excess consistent with a left aldosterone\u2010producing adenoma. The patient underwent robotic adrenalectomy with subsequent improvement in blood pressure control and reduced antihypertensive requirements. This case highlights the importance of evaluating for primary hyperaldosteronism in patients with ADPKD and resistant hypertension, even in the setting of advanced renal disease or prior nephrectomy.<\/jats:p>","DOI":"10.1002\/ccr3.72338","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:29:16Z","timestamp":1773980956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Hidden Culprit: Aldosteronoma as a Rare Cause of Refractory Hypertension in Autosomal\u2010Dominant Polycystic Kidney Disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-6909","authenticated-orcid":false,"given":"Matthew","family":"Wainstein","sequence":"first","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Mendonsa","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Folkman","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Nair","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Simpson","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaelee","family":"Storey","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Mount","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obi","family":"Ekwenna","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"},{"name":"Department of Urology and Transplantation The University of Toledo Heath Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.233"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010183231602"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft513"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010002\u20100032\u20101"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.927669"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010019\u201005074\u2010z"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_330_16"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V121194"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC\u201008\u20100094"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000018407.60002.b9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20104061"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.883"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(17)30135\u20103"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0272\u20106386(12)70287\u20101"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.051"},{"key":"e_1_2_11_17_1","volume-title":"Quick Answers Surgery","author":"Doherty G.","year":"2010"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000132473.50966.14"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000201443.63240.a7"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168725"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72338","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:07:59Z","timestamp":1774505279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.72338"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72338","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72338"}}