{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:04:27Z","timestamp":1784307867778,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Iron plays a vital role in physiological functions, and its deposition is typically limited to reticuloendothelial tissues in the presence of excess levels. We report a rare case of colonic iron deposition in a 13\u2010month\u2010old child without iron overload or toxicity. Despite a normal serum iron profile and administration of only prophylactic iron supplementation, histological examination revealed marked iron accumulation in the lamina propria of the colon. This unusual presentation emphasizes the need for awareness of possible iron\u2010related mucosal changes even in the absence of systemic overload, particularly in children with gastrointestinal or immunologic comorbidities.<\/jats:p>","DOI":"10.1002\/ccr3.72346","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:55:01Z","timestamp":1780372501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Colonic Iron Deposition Following Prophylactic Supplementation in an Infant: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Farid","family":"Imanzadeh","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-4995","authenticated-orcid":false,"given":"Mohammad Mahdi","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Iran University of Medical Sciences  Tehran Iran"},{"name":"Aliasghar Clinical Research Development Center, Department of Pediatrics, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Ramin","family":"Madani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Department of Pathology Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayyeh","family":"Jameie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.1.198"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02277-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03081.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-821-IMGMI"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"18506","article-title":"The Effectiveness of Omeprazole and Esomeprazole in Infants With Gastroesophageal Reflux Disease: A Comparative Study","volume":"12","author":"Madani R.","year":"2024","journal-title":"Journal of Pediatric Perspectives"},{"issue":"20","key":"e_1_2_8_7_1","first-page":"235","article-title":"Iron Deposition in Duodenal Mucosa","volume":"21","author":"Mahjoub F.","year":"2011","journal-title":"Iranian Journal of Pediatrics"},{"issue":"4","key":"e_1_2_8_8_1","first-page":"932","article-title":"Secondary Iron Overload and the Liver: A Comprehensive Review","volume":"11","author":"Pinyopornpanish K.","year":"2023","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04239-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.1.8633135"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21490"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199910000-00009"},{"key":"e_1_2_8_14_1","first-page":"1539","article-title":"Iiron Poisoning in Young Children: Association With the Birth of a Sibling","volume":"168","author":"Juurlink D. 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