{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:47:40Z","timestamp":1783525660818,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute intermittent porphyria (AIP) is a rare heme biosynthesis disorder in which the accumulation of neurotoxic porphyrin precursors precipitates neurovisceral attacks. Intercurrent infections, including coronavirus disease 2019 (COVID\u201019), may trigger or exacerbate AIP and complicate diagnosis, as clinical manifestations can resemble those of other acute neuropathies. This report describes a 16\u2010year\u2010old girl who developed abdominal pain, seizures, and rapidly progressive acute motor neuropathy shortly after COVID\u201019 and was initially misdiagnosed with Guillain\u2013Barr\u00e9 syndrome (GBS). Diagnostic evaluation included electrophysiological studies, biochemical assays for porphyrin precursors, and genetic testing. AIP was suspected based on electrophysiological findings and elevated porphyrin precursors. The patient improved after initiation of a 10% dextrose infusion and a high\u2010carbohydrate diet, with normalization of laboratory abnormalities. Subsequent genetic testing identified a heterozygous pathogenic\n                    <jats:italic>HMBS<\/jats:italic>\n                    variant (c.580C&gt;\u2009T), confirming AIP. COVID\u201019 may unmask AIP and mimic a GBS\u2010like neuropathy, increasing the risk of delayed recognition and suboptimal management. In patients with COVID\u201019\u2010associated acute neuropathy\u2014particularly when accompanied by abdominal pain, seizures, or neuropsychiatric features\u2014clinicians should include AIP in the differential diagnosis and pursue prompt biochemical evaluation (urine PBG and ALA) to facilitate early targeted therapy and prevent complications.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72417","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:38:49Z","timestamp":1777955929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Intermittent Porphyria Triggered by\n                    <scp>COVID<\/scp>\n                    \u201019 Mimicking Guillain\u2013Barr\u00e9 Syndrome: A Diagnostic Challenge"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3217-7199","authenticated-orcid":false,"given":"Payman","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Children's Medical Center Pediatrics Center of Excellence  Tehran Iran"},{"name":"Department of Pediatrics Tehran University of Medical Sciences  Tehran Iran"},{"name":"Pediatric Rheumatology Research Group, Rheumatology Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Pediatric Rheumatology Society of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood","family":"Ghahvechi Akbari","sequence":"additional","affiliation":[{"name":"Children's Medical Center Pediatrics Center of Excellence  Tehran Iran"},{"name":"Department of Physical Medicine and Rehabilitation Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Abbas","family":"Hassani","sequence":"additional","affiliation":[{"name":"Children's Medical Center Pediatrics Center of Excellence  Tehran Iran"},{"name":"Department of Pediatrics Tehran University of Medical Sciences  Tehran Iran"},{"name":"Division of Pediatric Intensive Care Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosein","family":"Alimadadi","sequence":"additional","affiliation":[{"name":"Children's Medical Center Pediatrics Center of Excellence  Tehran Iran"},{"name":"Department of Pediatrics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Heidari","sequence":"additional","affiliation":[{"name":"Children's Medical Center Pediatrics Center of Excellence  Tehran Iran"},{"name":"Department of Pediatrics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4648-3573","authenticated-orcid":false,"given":"Vahid","family":"Ziaee","sequence":"additional","affiliation":[{"name":"Children's Medical Center Pediatrics Center of Excellence  Tehran Iran"},{"name":"Department of Pediatrics Tehran University of Medical Sciences  Tehran Iran"},{"name":"Pediatric Rheumatology Research Group, Rheumatology Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Pediatric Rheumatology Society of Iran  Tehran 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