{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:00:27Z","timestamp":1781254827562,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>IgA nephropathy (IgAN) is the most frequently reported glomerular disease associated with inflammatory bowel disease (IBD), particularly Crohn's disease (CD), although pediatric cases remain rare. We report IgAN in a 16\u2010year\u2010old male with CD following intestinal surgery and during long\u2010term infliximab therapy, with renal impairment occurring independently of bowel disease activity. The patient presented with recurrent macroscopic hematuria, proteinuria, and acute kidney injury despite sustained intestinal remission. Renal biopsy confirmed IgAN (MEST\u2010C: M0, E0, S1, T0, C1). Treatment with renin\u2013angiotensin system (RAS) blockade and corticosteroids resulted in complete renal remission. Infliximab was discontinued, and a subsequent intestinal flare was successfully treated with ustekinumab. This case highlights the importance of vigilant renal monitoring in pediatric CD, particularly in patients with prior intestinal surgery or long\u2010term biologic therapy.<\/jats:p>","DOI":"10.1002\/ccr3.72418","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:07:44Z","timestamp":1775027264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Study and Review of the Literature on\n                    <scp>IgA<\/scp>\n                    Nephropathy in Crohn's Disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9193-799X","authenticated-orcid":false,"given":"Giovanna Fernanda","family":"Vazzana","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood \u201cG. Barresi\u201d University Hospital \u201cG. 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