{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:00:49Z","timestamp":1781254849713,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a case of primary central nervous system lymphoma (PCNSL) in a 40\u2010year\u2010old man with well\u2010controlled HIV infection, virologic suppression, and a near\u2010normal CD4 count who presented with new\u2010onset generalized seizures and left lower motor neuron facial palsy. Brain MRI showed a large left temporal lobe lesion with irregular ring enhancement, marked vasogenic edema and mild midline shift. Lumbar puncture was deferred due to mass effect. The patient was stabilized with anticonvulsants and supportive care and transferred for stereotactic biopsy and oncologic management. Stereotactic brain biopsy confirmed PCNSL, and the patient was initiated on high\u2010dose methotrexate\u2010based chemotherapy with adjunctive dexamethasone. This case highlights that PCNSL can occur despite immunologic preservation in HIV and may present acutely with seizures. Early contrast\u2010enhanced MRI, careful timing of corticosteroid use relative to biopsy, and timely referral are essential, particularly in resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/ccr3.72447","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:54:23Z","timestamp":1774842863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary\n                    <scp>CNS<\/scp>\n                    Lymphoma Presenting With Seizures in a Virologically Suppressed\n                    <scp>HIV<\/scp>\n                    Patient With Near\u2010Normal\n                    <scp>CD4<\/scp>\n                    : A Case Report From Uganda"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7328-3195","authenticated-orcid":false,"given":"Abdisalam Ahmed","family":"Sandeyl","sequence":"first","affiliation":[{"name":"Internal Medicine 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