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Herein, we present a case report of a previously healthy 60\u2010year\u2010old female presenting with periumbilical abdominal pain, vomiting, and difficulty in passing stool, with clinical workup, imaging, and surgery defining a small intestine tumor. Histology defined the tumor as a mesenteric pleomorphic leiomyosarcoma.<\/jats:p>","DOI":"10.1002\/ccr3.72451","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:41:37Z","timestamp":1778816497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleomorphic Leiomyosarcoma of the Jejunoileal Mesentery: A Histopathological Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-0615","authenticated-orcid":false,"given":"George S.","family":"Stoyanov","sequence":"first","affiliation":[{"name":"Department of Pathology Multiprofile Hospital for Active Treatment  Shumen Bulgaria"},{"name":"Laboratory of Cytopathology Diagnostic and Consultative Center  Shumen Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zlatko","family":"Zlatev","sequence":"additional","affiliation":[{"name":"Department of Pathology Multiprofile Hospital for Active Treatment  Shumen Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Kirilova","sequence":"additional","affiliation":[{"name":"Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine Medical University\u2014Varna  Varna Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Naydenova","sequence":"additional","affiliation":[{"name":"Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine Medical University\u2014Varna  Varna Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hristo","family":"Popov","sequence":"additional","affiliation":[{"name":"Department of General and Clinical Pathology, Forensic Medicine and Deontology, Faculty of Medicine Medical University\u2014Varna  Varna Bulgaria"},{"name":"Individual Medical Diagnostic Laboratory CityLab  Varna Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/HIS.12159"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12032\u2010016\u20100730\u20103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/S40792\u2010022\u201001497\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349\u20102902.ISJ20210399"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13569\u2010016\u20100042\u20106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19810815)48:4<1022::AID\u2010CNCR2820480429>3.0.CO;2\u20105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200007000\u201000004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.HUMPATH.2009.10.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200108000\u201000007"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102559.2011.04070.X"},{"key":"e_1_2_11_12_1","first-page":"125","article-title":"Leiomyosarcoma of Large and Small Veins: Clinical Findings and Results of Treatment in Six Patients","volume":"17","author":"Van Gulik T. 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