{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:25:27Z","timestamp":1789010727443,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pigmented Purpuric Dermatoses (PPD) are chronic conditions often resistant to standard treatments, creating a need for new therapies, particularly for those suffering from severe itching. This report details a patient with a year of refractory lower\u2010extremity PPD who failed multiple oral and topical treatments. The patient was then successfully treated with oral abrocitinib (100\u2009mg daily). Significant relief from pruritus occurred within 2\u2009weeks, and substantial improvement in the skin lesions followed by the sixth week. After 3\u2009months of treatment, lesions resolved to simple brown patches, with no recurrence seen during a four\u2010month follow\u2010up and no significant side effects noted. These results suggest that the JAK1 inhibitor abrocitinib possesses potential as a safe and highly effective treatment option for refractory PPD, warranting further clinical study.<\/jats:p>","DOI":"10.1002\/ccr3.72463","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:28:41Z","timestamp":1775795321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Treatment of Pigmented Purpuric Dermatoses With Abrocitinib: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1373-4568","authenticated-orcid":false,"given":"Yuping","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology Zhongshan City People's Hospital  Zhongshan, Guangdong Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiji","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongshan City People's Hospital  Zhongshan, Guangdong Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zhongshan City People's Hospital  Zhongshan, Guangdong Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112283"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1473553"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106210"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19616"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1991.tb01378.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.10.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S338661"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00701-3"},{"issue":"1","key":"e_1_2_13_10_1","first-page":"4","article-title":"Janus Kinase and Tyrosine Kinase Inhibitors in Dermatology: A Review of Their Utilization, Safety Profile and Future Applications","volume":"27","author":"Shalabi M.","year":"2022","journal-title":"Skin Therapy Letter"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72463","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:40:08Z","timestamp":1781253608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ccr3.72463"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72463","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.176037321.13546162\/v1","asserted-by":"object"}]},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72463"}}