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This case report illustrates the diagnostic complexity of APS and underscores the importance of considering central nervous system etiologies in patients with unexplained, refractory gastrointestinal symptoms, particularly in younger individuals. Early recognition through brain magnetic resonance imaging (MRI) and serologic testing for aquaporin\u20104 immunoglobulin G (AQP4\u2010IgG) antibodies is essential, as it enables prompt initiation of high\u2010dose corticosteroid therapy and appropriate long\u2010term immunomodulatory treatment. Delayed diagnosis may result in cumulative neurological injury, including severe complications such as optic neuritis. This case highlights the critical role of a multidisciplinary approach in the evaluation and management of APS, to prevent irreversible neurological disability.<\/jats:p>","DOI":"10.1002\/ccr3.72472","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:06:24Z","timestamp":1783670784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Challenges and Clinical Management of Area Postrema Syndrome: A Case Report on Persistent Nausea and Vomiting"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1653-3034","authenticated-orcid":false,"given":"Andreea\u2010Gabriela","family":"Manole","sequence":"first","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ion","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy  Bucharest Romania"},{"name":"University Emergency Hospital of Bucharest  Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bolocan","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy  Bucharest Romania"},{"name":"University Emergency Hospital of Bucharest  Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Andronic","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy  Bucharest Romania"},{"name":"General Surgery Department CF2 Clinical Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. N.","family":"P\u0103duraru","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy  Bucharest Romania"},{"name":"General Surgery Department CF2 Clinical Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"StatPearls [Internet]","author":"Mirza M.","year":"2025"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-822404-5.00010-3"},{"key":"e_1_2_13_4_1","unstructured":"A.Rezaee \u201cRadiopaedia [Internet] \u201d[cited January 17 2026] Area postrema | Radiology Reference Article | Radiopaedia.org https:\/\/radiopaedia.org\/articles\/area\u2010postrema."},{"key":"e_1_2_13_5_1","volume-title":"StatPearls [Internet]","author":"MacDougall M. 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