{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:59:15Z","timestamp":1781254755673,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a case of chronic granulomatous invasive aspergillosis in a 56\u2010year\u2010old male teacher from South Kordofan, Sudan, who underwent surgery in 2007 to remove his left orbital aspergillus granuloma. The patient developed progressive facial swelling beginning in 2017 and paraesthesia in the left zygomatico\u2010maxillary region, despite initial treatment. A soft tissue mass in the left maxillary sinus and widespread bone loss affecting the zygomatic arch, maxillary antrum, and fronto\u2010temporal lytic lesions were seen on computed tomography. Histopathological analysis confirmed the recurrence of aspergillosis. Itraconazole therapy was administered to the patient after surgical excision, although treatment compliance was subpar. A subsequent wide local excision was performed in 2021, but the patient developed post\u2010operative complications, including wound infection and dysphagia, leading to death four days after surgery. This case highlights the aggressive nature of chronic invasive aspergillosis, the importance of adequate initial treatment duration, and the potential for devastating complications, including facial bone destruction and neurological involvement manifesting as paresthesia.<\/jats:p>","DOI":"10.1002\/ccr3.72477","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:55:44Z","timestamp":1775267744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paresthesia and Facial Bone Destruction due to Chronic Granulomatous Invasive Aspergillosis in the Left Maxillary Sinus"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-4982","authenticated-orcid":false,"given":"Rawa","family":"Badri","sequence":"first","affiliation":[{"name":"The Mycetoma Research Centre University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Hassan","family":"Fahal","sequence":"additional","affiliation":[{"name":"The Mycetoma Research Centre University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001011"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.280"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196505000-00004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809124751"},{"issue":"2","key":"e_1_2_13_6_1","first-page":"90","article-title":"Nasosinus Aspergillosis in Sudanese Patients: Clinical Features, Pathology, Diagnosis, and Treatment","volume":"28","author":"Yagi H. I.","year":"1999","journal-title":"Journal of Otolaryngology \u2010 Head & Neck Surgery"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(96)80004-X"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300621"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900110031005"},{"issue":"1","key":"e_1_2_13_10_1","first-page":"1","article-title":"Epidemiology and Medical Mycology of Fungal Rhinosinusitis","volume":"1","author":"Chatterjee S. S.","year":"2009","journal-title":"Otorhinolaryngologic Clinics of North America"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010013\u20101123"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/513662"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-019-0707-4"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000507"},{"issue":"7","key":"e_1_2_13_15_1","first-page":"1189","article-title":"Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence\u2010Based Review With Recommendations","volume":"13","author":"Roland L. T.","year":"2023","journal-title":"International Forum of Allergy & Rhinology"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200007000-00006"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-28618-1_1737"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.12.015"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51571"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540891003"},{"key":"e_1_2_13_22_1","first-page":"661","article-title":"Sino\u2010Orbital Aspergillosis","volume":"55","author":"Zinneman H. H.","year":"1972","journal-title":"Minnesota Medicine"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1700685"},{"issue":"2","key":"e_1_2_13_24_1","first-page":"232","article-title":"Chronic Granulomatous Invasive Fungal Sinusitis: A Review of the Literature and Report of a Case Atypical of the Balkan Region","volume":"40","author":"Labus M.","year":"2023","journal-title":"Acta Facultatis Medicae Naissensis"},{"key":"e_1_2_13_25_1","unstructured":"The Skeletal System \u201cSkull Bones: Structure Functions and Diagrams \u201d."},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020212"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2023.05.001"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.12.76"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1443487"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.002"},{"issue":"3","key":"e_1_2_13_31_1","first-page":"154","article-title":"Combination Antifungal Therapy for Invasive Aspergillosis: Can it Replace High\u2010Risk Surgery at the Skull Base?","volume":"29","author":"Panda N. K.","year":"2008","journal-title":"American Journal of Otolaryngology"},{"issue":"3","key":"e_1_2_13_32_1","first-page":"7","article-title":"Invasive Sino\u2010Aspergillosis in Immunocompetent Individuals: A Typical Presentations","volume":"2","author":"Gupta A.","year":"2009","journal-title":"Clin Rhinol an Int J"},{"issue":"10","key":"e_1_2_13_33_1","first-page":"e3483","article-title":"Isavuconazole Treatment of Invasive Fungal Sinusitis: A Post Hoc Analysis of the SECURE and VITAL Trials","volume":"73","author":"Durand M. L.","year":"2021","journal-title":"Clinical Infectious Diseases"},{"issue":"12","key":"e_1_2_13_34_1","first-page":"1131","article-title":"Advances in Management of Paranasal Sinus Aspergillosis","volume":"121","author":"Daudia A.","year":"2007","journal-title":"Journal of Laryngology and Otology"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac492.039"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:39:56Z","timestamp":1781253596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ccr3.72477"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72477","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72477"}}