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Here, we report a case of a 46\u2010year\u2010old male with amlodipine (420\u2009mg) and ethanol intoxication who unexpectedly presented without severe hypotension or shock. Instead, his main manifestation was acute renal function loss requiring hemodialysis. The potential pathological mechanism may be acute kidney injury (AKI) caused by transient renal ischemic insult, while ethanol may exacerbate acute tubular necrosis (ATN).<\/jats:p>","DOI":"10.1002\/ccr3.72529","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:37:22Z","timestamp":1776314242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of Acute Renal Failure due to Amlodipine Overdose and Alcohol Consumption"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3109-9599","authenticated-orcid":false,"given":"Yi","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Nephrology, Wusong Branch Zhongshan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"issue":"10","key":"e_1_2_11_2_1","first-page":"993","article-title":"Analysis of Prescription and Rationality of Anti\u2010Hypertensive Medication Among Community Health Centers in Beijing","volume":"49","author":"Bai J. 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