{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:00:50Z","timestamp":1781254850765,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Xanthogranulomatous pyelonephritis (XGP) is a rare, chronic, and destructive renal inflammatory disease that often mimics renal malignancy, presenting significant diagnostic challenges, particularly in patients with end\u2010stage renal disease (ESRD). We report a 55\u2010year\u2010old African man with diabetes mellitus, hypertension, and ESRD on hemodialysis who presented with progressive dyspnea and fluid overload. Imaging revealed bilateral heterogeneous renal masses highly suggestive of renal cell carcinoma; however, limited diagnostic resources and his unstable condition precluded advanced imaging or early tissue sampling. Histopathological examination later confirmed XGP, showing diffuse infiltration by lipid\u2010laden macrophages, chronic inflammatory cells, and multinucleated giant cells. The patient deteriorated and died before results became available. This case highlights the difficulty of distinguishing XGP from renal malignancy in resource\u2010constrained settings, underscores the importance of early histopathological evaluation where feasible, and emphasizes the need for heightened clinical awareness to avoid misdiagnosis and delays in appropriate management.<\/jats:p>","DOI":"10.1002\/ccr3.72562","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:39:02Z","timestamp":1776483542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management Challenges of Bilateral Xanthogranulomatous Pyelonephritis in a Patient With End\u2010Stage Renal Disease in a Low\u2010Resource Setting: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Abitalis","family":"Mayengela","sequence":"first","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deardiana","family":"Sengelela","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angubwike","family":"Mwakitwange","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremia J.","family":"Pyuza","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furaha","family":"Kasyupa","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pallangyo","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Amsi","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Nkya","sequence":"additional","affiliation":[{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furaha","family":"Lyamuya","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Internal Medicine Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Mremi","sequence":"additional","affiliation":[{"name":"School of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"Department of Research and Training Kilimanjaro Clinical Research Institute  Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/2009\u20100769\u2010RSR.1"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.70774"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000474"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44118"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/2175\u20108239\u2010JBN\u20102020\u20100242"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_50_18"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15878"},{"issue":"8","key":"e_1_2_14_9_1","first-page":"495","article-title":"Xanthogranulomatous Pyelonephritis in Adults: Clinical,Biological, Radiologica and Therapeutic Main Findings in Diffuse and Focal Forms.About 42 Cases","volume":"96","author":"Ichaoui H.","year":"2018","journal-title":"Tunisie Medicale"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047981613513763"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2022.11.004"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2021.105943"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u2010139X.2006.00175.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.67.e139995"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.09.026"}],"container-title":["Clinical Case 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