{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:04:48Z","timestamp":1777046688083,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Primary sublingual gland small cell neuroendocrine carcinoma (SCNEC) is extremely rare, with only one prior case reported, and no site\u2010specific standard of care has been established. We report a case of primary sublingual gland SCNEC treated with definitive concurrent chemoradiotherapy (CRT). A 69\u2010year\u2010old man presented with a 21\u2009\u00d7\u200915\u2010mm right sublingual mass showing fluorodeoxyglucose uptake (SUVmax 9.9) on PET\/CT. No nodal or distant disease was found. Biopsy revealed small cell morphology positive for INSM1\/synaptophysin and pan\u2010cytokeratin, with a high Ki\u201067 index (&gt;\u200995%). IMRT delivered 70\u2009Gy in 35 fractions to the primary tumor with elective bilateral nodal irradiation (levels I\u2013V, 46\u2009Gy). Cisplatin (80\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ; day 1) and etoposide (100\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ; days 1\u20133) were administered every 3\u2009weeks for four cycles. Grade 3 oral mucositis and grade 2 neutropenia resolved. At 24\u2009months post\u2010CRT, the patient remains disease\u2010free with preserved daily function. Definitive concurrent CRT appears to be a feasible and effective organ\u2010preserving treatment option for limited\u2010stage primary sublingual gland SCNEC, with durable disease control at 24\u2009months in this case.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72565","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:01:58Z","timestamp":1777042918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Small Cell Neuroendocrine Carcinoma of the Sublingual Gland Treated With Definitive Chemoradiotherapy: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7255-4549","authenticated-orcid":false,"given":"Taka\u2010aki","family":"Tokura","sequence":"first","affiliation":[{"name":"Department of Oral Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironari","family":"Dehari","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koyo","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-1161","authenticated-orcid":false,"given":"Sho","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7685-2492","authenticated-orcid":false,"given":"Takanori","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-9223","authenticated-orcid":false,"given":"Kazuhiro","family":"Ogi","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Someya","sequence":"additional","affiliation":[{"name":"Department of Radiology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-9442","authenticated-orcid":false,"given":"Kohichi","family":"Takada","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kitajo","sequence":"additional","affiliation":[{"name":"Sapporo Teine Dental and Oral Surgery Clinic  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-6205","authenticated-orcid":false,"given":"Akihiro","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2020.1846024"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1166424"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16281"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018\u20100054"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21952"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.04.003"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21785"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30318\u20102"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0312455"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1049116"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489419853174"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320959585"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010022\u201001409\u20106"}],"container-title":["Clinical 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