{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:59:20Z","timestamp":1781254760088,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This case demonstrates the value of cell\u2010free DNA (cfDNA) screening for detecting subchromosomal microdeletions in fetuses with non\u2010specific prenatal screening abnormalities and no overt structural malformations on ultrasound; CMA and karyotyping confirmation and integrated genetic counseling are essential for diagnosing 5q14.3q15 deletion\u2010related BBSOAS and guiding parental decision\u2010making.<\/jats:p>","DOI":"10.1002\/ccr3.72581","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T04:18:30Z","timestamp":1776658710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Second Prenatal Diagnosis of Bosch\u2013Boonstra\u2013Schaaf Optic Atrophy Syndrome in a Fetus With a 5q14.3q15 Deletion: A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-5813","authenticated-orcid":false,"given":"Ying","family":"Hao","sequence":"first","affiliation":[{"name":"Medical Genetic Center, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center Southern Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfa","family":"Huang","sequence":"additional","affiliation":[{"name":"Medical Genetic Center, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center Southern Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical Genetic Center, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center Southern Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingping","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Genetic Center, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center Southern Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4746-4905","authenticated-orcid":false,"given":"Peining","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Genetic Center, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center Southern Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Genetic Center, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center Southern Medical University  Shenzhen Guangdong China"},{"name":"Shenzhen Key Laboratory of Maternal and Child Health and Diseases  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlan","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Genetic Center, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center Southern Medical University  Shenzhen Guangdong China"},{"name":"Shenzhen Key Laboratory of Maternal and Child Health and Diseases  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.01.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.18"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61580"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.767965"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081260"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14731"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030558"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.961196"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000336339.08878.2d"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35650"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab162"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2025.2522365"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019104163"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29198"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.11.016"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14911"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2020.104019"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:40:04Z","timestamp":1781253604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ccr3.72581"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72581","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72581"}}