{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:45:13Z","timestamp":1777031113438,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tall cell carcinoma of the breast with reversed polarity (TCCRP) is a rare type of invasive breast cancer with overlapping histopathological features with papillary thyroid carcinoma and a characteristic immunohistochemical (IHC) and molecular profile.\n                    <jats:italic>Case Presentation:<\/jats:italic>\n                    A 72\u2010year\u2010old female presented with a left breast mass and purulent nipple discharge. Imaging showed a BI\u2010RADS 4 lesion on mammography and a heterogeneous, lobulated mass on computed tomography (CT), confined to the breast. Core biopsy suggested low\u2010grade invasive carcinoma. She underwent a left simple mastectomy with sentinel lymph node biopsy. Histopathology was consistent with features of TCCRP. IHC and molecular analysis revealed a hormone receptor (HR)\u2010positive TCCRP with\n                    <jats:italic>IDH1 R132<\/jats:italic>\n                    mutation with low proliferative index. The patient received adjuvant radiotherapy (40\u2009Gy\/15 fractions) and is under 5\u2010year letrozole therapy. At 18\u2010month follow\u2010up, she remained disease\u2010free, with no recurrence or metastasis. This case underscores the clinical, histopathological, immunophenotypic, and molecular features of TCCRP, including the rare\n                    <jats:italic>IDH1 R132H<\/jats:italic>\n                    mutation. Timely surgical and hormonal therapy ensures excellent prognosis, and future studies on targeted\n                    <jats:italic>IDH1\/IDH2<\/jats:italic>\n                    and\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    therapies may expand treatment options.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72599","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:10:46Z","timestamp":1777029046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tall Cell Carcinoma of the Breast With Reverse Polarity: Expanding the Molecular Spectrum With\n                    <i>IDH1 R132<\/i>\n                    Mutation"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3855-450X","authenticated-orcid":false,"given":"Abhisek","family":"Jha","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology Birat Medical College and Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9963-7481","authenticated-orcid":false,"given":"Shristi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Birat Medical College and Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmita","family":"Rayamajhi","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Birat Medical College and Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajan","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Birat Medical College and Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuldeep","family":"Timilsina","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Birat Medical College and Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragati","family":"Gurung","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Birat Medical College and Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit Kumar","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Birat Medical College and Teaching Hospital  Morang Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200308000\u201000008"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13522"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201016\u20100298"},{"key":"e_1_2_13_5_1","unstructured":"G.Kwon G.Nam 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