{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:34:04Z","timestamp":1777286044738,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cutaneous hyperpigmentation, an overlooked manifestation, can be an early sign of vitamin B12 deficiency. This case highlights symmetric pigmentation on the dorsum of hands and palms in a long\u2010term vegetarian. Recognizing such subtle skin changes aids early diagnosis. Timely treatment reverses both pigmentation and systemic symptoms, underscoring its clinical relevance.<\/jats:p>","DOI":"10.1002\/ccr3.72634","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:39:53Z","timestamp":1777282793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skin Hyperpigmentation: An Under\u2010Recognized Dermatological Clue to Vitamin B12 Deficiency"],"prefix":"10.1002","volume":"14","author":[{"given":"Mahesh","family":"Mathur","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medical Sciences  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Paudel","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medical Sciences  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6438-1930","authenticated-orcid":false,"given":"Sambidha","family":"Karki","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medical Sciences  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5844-8910","authenticated-orcid":false,"given":"Sandhya","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medical Sciences  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Maharjan","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medical Sciences  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2859-0376","authenticated-orcid":false,"given":"Nabita","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medical Sciences  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.18203\/2320-6012.ijrms20191706","article-title":"A Case Report on Hyperpigmentation in Vitamin B12 Deficiency","volume":"7","author":"Verma V. K.","year":"2019","journal-title":"International Journal of Research in Medical Sciences"},{"issue":"4","key":"e_1_2_17_3_1","first-page":"529","article-title":"Cutaneous Lesions and Vitamin B12 Deficiency: An Often\u2010Forgotten Link","volume":"54","author":"Kannan R.","year":"2008","journal-title":"Canadian Family Physician M\u00e9decin de Famille Canadien [Internet]"},{"key":"e_1_2_17_4_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4103\/2230-8210.119591","article-title":"Pigmentation in Vitamin B12 Deficiency Masquerading Addison's Pigmentation: A Rare Presentation","volume":"17","author":"Agrawala R.","year":"2013","journal-title":"Indian Journal of Endocrinology and Metabolism"},{"key":"e_1_2_17_5_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189694","article-title":"A Brief Review on Vitamin B12 Deficiency Looking at Some Case Study Reports in Adults","volume":"22","author":"Azzini E.","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_17_6_1","unstructured":"\u201cOffice of Dietary Supplements \u2013 Vitamin B12 [Internet] \u201daccessed April 7 2025 https:\/\/ods.od.nih.gov\/factsheets\/VitaminB12\u2010Consumer."},{"key":"e_1_2_17_7_1","volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline [Internet]","author":"Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline","year":"1998"},{"issue":"2","key":"e_1_2_17_8_1","article-title":"Low Vitamin B12 Levels: An Underestimated Cause of Minimal Cognitive Impairment and Dementia","volume":"12","author":"Jatoi S.","year":"2020","journal-title":"Cureus [Internet]"},{"key":"e_1_2_17_9_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.25259\/IJPGD_116_2023","article-title":"Reversible Hyperpigmentation due to Vitamin B12 Deficiency \u2010 Mimicking Addison's Pigmentation","volume":"2","author":"Vijay V.","year":"2024","journal-title":"Indian Journal of Postgraduate Dermatology"},{"issue":"7","key":"e_1_2_17_10_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.59556\/japi.72.0570","article-title":"Dermatological Conundrum: Puzzling Pigmentation in Vitamin B12 Deficiency and Addison's Disease","volume":"72","author":"Bawaskar H. S.","year":"2024","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_17_11_1","volume-title":"StatPearls [Internet]","author":"Khan K. M.","year":"2025"},{"key":"e_1_2_17_12_1","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.amjmed.2023.07.011","article-title":"Chakraborty U Primary Adrenal Insufficiency and Hyperpigmentation","volume":"136","author":"Majumder M.","year":"2023","journal-title":"American Journal of Medicine"},{"key":"e_1_2_17_13_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jdcr.2025.08.019","article-title":"Sudden\u2010Onset Diffuse Cutaneous Hyperpigmentation as an Unusual Early Sign of Systemic Sclerosis","volume":"65","author":"Rajaibi R. A.","year":"2025","journal-title":"JAAD Case Reports"},{"issue":"4","key":"e_1_2_17_14_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4103\/0019-5154.57609","article-title":"Dermatological Manifestations in HIV\u2010Infected Patients at a Tertiary Care Hospital in a Tribal (BASTAR) Region of Chhattisgarh, India","volume":"54","author":"Singh H.","year":"2009","journal-title":"Indian Journal of Dermatology"},{"issue":"11","key":"e_1_2_17_15_1","first-page":"1513","article-title":"A Case of Generalized Hyperpigmentation Caused by Antituberculosis Drugs","volume":"46","author":"Kim B. S.","year":"2008","journal-title":"Korean Journal of Dermatology"},{"issue":"9","key":"e_1_2_17_16_1","article-title":"Hyperpigmentation as a Primary Symptom of Vitamin B12 Deficiency: A Case Report","volume":"14","author":"Jangda A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_17_17_1","volume-title":"Nottinghamshire Guidelines on the Diagnosis and Management of Vitamin B12 Replacement in Primary Care [Internet]","author":"Nottinghamshire Area Prescribing Committee","year":"2025"},{"issue":"5","key":"e_1_2_17_18_1","article-title":"The Neurological Sequelae of Vitamin B12 Deficiency: A Systematic Review and Randomized Controlled Trial","volume":"17","author":"Hamza Ali A. A.","year":"2025","journal-title":"Cureus"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72634","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:39:58Z","timestamp":1777282798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ccr3.72634"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72634","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"2025-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72634"}}