{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:24:58Z","timestamp":1780514698595,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n The central nervous system (CNS) is the most common site of extramedullary relapse in acute lymphoblastic leukemia (ALL). However, the diagnosis may be challenging due to its protean manifestations. A 64\u2010year\u2010old male reported right\u2010sided hearing loss with intermittent bilateral occipitotemporal headaches during a clinic follow\u2010up for Ph\u2009+\u2009B\u2010ALL. His yearling and neurological symptoms persisted, with two unremarkable MRI brains. However, a repeat MRI showed findings suspicious for a vestibular schwannoma. Isolated CNS relapse of B\u2010ALL was subsequently confirmed on lumbar puncture. He received intrathecal and dasatinib therapy, which was complicated by cytomegalovirus (CMV) colitis and\n \n Granulicatella adiacens<\/jats:italic>\n <\/jats:styled-content>\n native aortic valve infective endocarditis. Subsequently, he received craniospinal irradiation followed by haploidentical allogeneic stem cell transplant (alloSCT) and has remained in molecular remission. This case of isolated CNS relapse of B\u2010ALL with\n BCR::ABL1<\/jats:italic>\n fusion illustrates some diagnostic and treatment challenges, including presenting symptoms and imaging findings that mimicked a vestibular schwannoma. The case also contributes to the limited literature reporting systemic CMV infections associated with dasatinib. In addition, it extends the spectrum of reported dasatinib\u2010associated infections to include\n \n Granulicatella adiacens<\/jats:italic>\n <\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1002\/ccr3.72670","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:41:23Z","timestamp":1778496083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["B\u2010Lymphoblastic Leukemia With Isolated Central Nervous System Relapse Mimicking a Vestibular Schwannoma"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-4696","authenticated-orcid":false,"given":"Jun Yen","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Haematology Canberra Hospital Canberra Australia"},{"name":"School of Medicine and Psychology, College of Health and Medicine Australian National University Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivendra T.","family":"Lalloo","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Canberra Hospital Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Milliken","sequence":"additional","affiliation":[{"name":"Department of Haematology St Vincent's Hospital Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N.","family":"Polizzotto","sequence":"additional","affiliation":[{"name":"Department of Haematology Canberra Hospital Canberra Australia"},{"name":"School of Medicine and Psychology, College of Health and Medicine Australian National University Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.5273.5273"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01075"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01709-y"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.014274"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-208699"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18537"},{"key":"e_1_2_13_8_1","article-title":"Relapse Patterns Focusing on Central Nervous System Involvement After Allogeneic Hematopoietic Cell Transplantation in Adult Patients With Acute Lymphoblastic Leukemia","volume":"1","author":"Lee J. 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