{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:10:15Z","timestamp":1778839815597,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a rare case of a 61\u2010year\u2010old woman with two distinct migraine patterns\u2014migraine without aura and typical aura without headache\u2014coexisting independently for 3\u2009years without overlapping typical aura with headache. Neurological evaluations were unremarkable. Sodium valproate significantly reduced the frequency of both types. This case underscores the importance of accurate classification and individualized management strategies, especially in atypical migraine phenotypes such as aura without headache.<\/jats:p>","DOI":"10.1002\/ccr3.72680","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:34:07Z","timestamp":1778837647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Both Migraine Without Aura and Typical Aura Without Headache in the Absence of Typical Aura With Headache"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-2530","authenticated-orcid":false,"given":"Osamu","family":"Akiyama","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Juntendo University Faculty of Medicine  Tokyo Japan"},{"name":"Akiyama Neurosurgical Clinic  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihide","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Akiyama Neurosurgical Clinic  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"issue":"1","key":"e_1_2_15_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd Edition","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"issue":"12","key":"e_1_2_15_3_1","first-page":"1656","article-title":"Characteristics of Migraine Visual Aura: A Review","volume":"39","author":"Queiroz L. P.","year":"2019","journal-title":"Cephalalgia"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.1077737"},{"issue":"4","key":"e_1_2_15_5_1","first-page":"413","article-title":"Migraine Aura Without Headache: Clinical Features and Long\u2010Term Follow\u2010Up","volume":"36","author":"Viana M.","year":"2016","journal-title":"Cephalalgia"},{"issue":"8","key":"e_1_2_15_6_1","first-page":"612","article-title":"The Premonitory Symptoms (Prodrome): A Tertiary Care Study of 893 Migraineurs","volume":"24","author":"Kelman L.","year":"2004","journal-title":"Cephalalgia"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010023\u201001647\u20105"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010012\u20106423\u20108"},{"issue":"1","key":"e_1_2_15_9_1","first-page":"S3","article-title":"Migraine: Epidemiology, Impact, and Risk Factors for Progression","volume":"45","author":"Lipton R. B.","year":"2005","journal-title":"Headache"},{"issue":"1","key":"e_1_2_15_10_1","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-018-0846-2","article-title":"Migraine Is First Cause of Disability in Under 50s: Will Health Politicians Now Take Notice?","volume":"19","author":"Steiner T. J.","year":"2018","journal-title":"Journal of Headache and Pain"},{"issue":"5","key":"e_1_2_15_11_1","first-page":"266","article-title":"Stroke Mimics: Neuroimaging and Clinical Features Distinguish Migraine Aura","volume":"15","author":"Rothrock J. F.","year":"2009","journal-title":"Neurologist"},{"issue":"5","key":"e_1_2_15_12_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/01.STR.17.5.1033","article-title":"Late\u2010Life Migraine Accompaniments\u2014Further Experience","volume":"17","author":"Fisher C. M.","year":"1986","journal-title":"Stroke"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14682"},{"key":"e_1_2_15_14_1","volume-title":"Chronic Headache Clinical Practice Guideline 2021","author":"Japanese Headache Society","year":"2021"},{"issue":"1","key":"e_1_2_15_15_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/brain\/117.1.199","article-title":"Pathophysiology of the Migraine Aura","volume":"117","author":"Lauritzen M.","year":"1994","journal-title":"Brain"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint17070104"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003168"},{"issue":"8","key":"e_1_2_15_18_1","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1073\/pnas.071582498","article-title":"Mechanisms of Migraine Aura Revealed by fMRI in Human Visual Cortex","volume":"98","author":"Hadjikhani N.","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"e_1_2_15_19_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1526-4610.2010.01647.x","article-title":"Cortical Spreading Depression Triggers Migraine Attack: Pro","volume":"50","author":"Ayata C.","year":"2010","journal-title":"Headache"},{"issue":"10","key":"e_1_2_15_20_1","first-page":"877","article-title":"Migraine Aura Triggered by Visual Stimulation: Electrophysiologic and Pharmacologic Evidence","volume":"23","author":"Pascual J.","year":"2003","journal-title":"Cephalalgia"},{"issue":"19","key":"e_1_2_15_21_1","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1001\/jama.2018.4853","article-title":"Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine","volume":"319","author":"Dodick D. W.","year":"2018","journal-title":"Journal of the American Medical Association"},{"issue":"8","key":"e_1_2_15_22_1","first-page":"901","article-title":"Psychiatric Comorbidities of Episodic and Chronic Migraine","volume":"84","author":"Buse D. C.","year":"2013","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"7482","key":"e_1_2_15_23_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.38302.504063.8F","article-title":"Risk of Ischemic Stroke in People With Migraine: Meta\u2010Analysis of Observational Studies","volume":"330","author":"Etminan M.","year":"2005","journal-title":"BMJ"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:34:10Z","timestamp":1778837650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ccr3.72680"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72680","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72680"}}