{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:41Z","timestamp":1753862861527,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"Key clinical message<\/jats:title>5\u2010<\/jats:bold>Alpha reductase deficiency is an important cause of 46, XY disorder of sex development. Timely diagnosis and proper management by a multidisciplinary team can lead to a favorable outcome. Sex assignment should be deferred until puberty because spontaneous virilization occurs and the patient can engage in the decision\u2010making process.<\/jats:p><\/jats:sec>Abstract<\/jats:title>5\u2010Alpha reductase deficiency is a genetic disorder causing 46, XY disorder of sex development (DSD). Typical clinical feature is a male with ambiguous genitalia or undervirilization at birth. Here we report three cases of this disorder within a family.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7269","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:57:32Z","timestamp":1683784652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["5\u2010Alpha reductase deficiency; an important cause of 46, XY DSD<\/scp>: Report of three cases within a family"],"prefix":"10.1002","volume":"11","author":[{"given":"Samaneh","family":"Noroozi\u00a0Asl","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Ibrahimi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-7347","authenticated-orcid":false,"given":"Sepideh","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.098319"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60071-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-005-4339-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1024"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/iju.IJU_340_20"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2005.18.12.1383"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313372"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2022.03.019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1189-4"},{"issue":"90","key":"e_1_2_11_12_1","first-page":"e11","article-title":"Identification of mutations in the SRD5A2 gene in Thai patients with male pseudohermaphroditism","volume":"2008","author":"Sahakitrungruang T","year":"2015","journal-title":"Fertil Steril"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.3.314"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2008.21.2.173"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2005.18.4.339"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000047621.66463.29"},{"issue":"64","key":"e_1_2_11_17_1","first-page":"76","article-title":"Male pseudohermaphroditism due to steroid 5alpha\u2010reductase 2 deficiency. 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