{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:06:21Z","timestamp":1779167181705,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this clinical case report, we present two immunocompetent patients with tubo\u2010ovarian abscesses (TOAs) that were positive for\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    . TOAs usually develop as a complex and severe complication of pelvic inflammatory disease, primarily have a polymicrobial etiology, and nearly all causative pathogens are bacteria. But, more rarely, fungal species are also isolated\n                    <jats:sup>1\u20133<\/jats:sup>\n                    . Both patients presented to our hospital with TOAs that were refractory to the usual management involving antibiotics and drainage, and after the identification of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. glabrata<\/jats:italic>\n                    <\/jats:styled-content>\n                    in abscess cultures, they were successfully treated with caspofungin. The first patient, a 34\u2010year\u2010old female, presented from an outside hospital after a TOA diagnosis, for which she was treated with intravenous (IV) antibiotics and the placement of an endoscopic stent between the abscess and the sigmoid colon. The patient was managed with transvaginal drainage and multiple rounds of antibiotics during two hospitalizations. After abscess cultures grew\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. glabrata<\/jats:italic>\n                    <\/jats:styled-content>\n                    , caspofungin was added to her treatment, and this resulted in clinical improvement. The second patient, a 39\u2010year\u2010old female diagnosed with a TOA after presenting with sepsis, was initially treated with IV antibiotics for four weeks and underwent percutaneous drainage. After minimal improvement, laparoscopic evacuation was performed, and the cultures grew\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. glabrata<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Caspofungin was added, and follow\u2010up imaging two weeks later showed complete resolution of the TOA. Fungal species may contribute to TOAs, and our experience suggests that adding caspofungin to the usual treatment may be effective, although surgery may additionally be necessary. Even without significant risk factors, treatment with antifungals should be considered for patients not improving with typical management that includes antibiotics and percutaneous drainage.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72693","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:09:37Z","timestamp":1779163777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Candida glabrata<\/i>\n                    Isolated From Tubo\u2010Ovarian Abscess Cultures in Two Immunocompetent Patients"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9316-5688","authenticated-orcid":false,"given":"Marlee","family":"Hirsch","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lenox Hill Hospital, Northwell Health  New York USA"},{"name":"Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra and Northwell  Uniondale New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalie","family":"DePaola","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lenox Hill Hospital, Northwell Health  New York USA"},{"name":"Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra and Northwell  Uniondale New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lenox Hill Hospital, Northwell Health  New York USA"},{"name":"Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra and Northwell  Uniondale New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Shay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lenox Hill Hospital, Northwell Health  New York USA"},{"name":"Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra and Northwell  Uniondale New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering NYU Tandon School of Engineering  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lenox Hill Hospital, Northwell Health  New York USA"},{"name":"Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra and Northwell  Uniondale New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering NYU Tandon School of Engineering  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.958210"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(85)90392\u20108"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1701\u20102163(15)30257\u20107"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa771"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/ahmt.S115535"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab067"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.5.876"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2009.01.010"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omz071"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13932"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.70100"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/514720"},{"issue":"1","key":"e_1_2_15_14_1","first-page":"25","article-title":"Pelvic Actinomycosis Associated With Use of Intrauterine Device: A New Challenge for the Surgeon","volume":"48","author":"Doberneck R. 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