{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:04:41Z","timestamp":1784307881006,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Olfactory neuroblastoma is a rare neuroendocrine tumor typically arising from the superior nasal cavity, and primary occurrence in the maxillary sinus is exceptionally uncommon, often leading to diagnostic confusion with other sinonasal malignancies. A 34\u2010year\u2010old man presented with bilateral nasal obstruction, recurrent epistaxis, and frontal headache, and imaging revealed a right maxillary sinus mass. Initial endoscopic biopsy suggested a differentiated neuroendocrine tumor, but whole\u2010body octreotide scintigraphy was negative. The patient underwent endoscopic endonasal medial maxillectomy with complete tumor resection. Final histopathology demonstrated small round blue cells in lobular architecture, strong chromogranin and synaptophysin positivity, absence of mitoses or necrosis, and a low Ki\u201067 index, confirming Hyams grade I olfactory neuroblastoma. Adjuvant intensity\u2010modulated radiotherapy was administered. The postoperative course was uneventful, and at 12\u2010month follow\u2010up there was no evidence of recurrence or metastasis. This case highlights that ectopic maxillary sinus olfactory neuroblastoma can mimic neuroendocrine carcinoma on limited biopsy, emphasizing the importance of complete resection and thorough histopathological evaluation for accurate diagnosis and grading. Hyams grade I disease in atypical locations carries an excellent prognosis with combined endoscopic surgery and radiotherapy, underscoring the prognostic value of Hyams grading and the need for long\u2010term surveillance.<\/jats:p>","DOI":"10.1002\/ccr3.72759","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:55:44Z","timestamp":1779335744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ectopic Olfactory Neuroblastoma of the Maxillary Sinus: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Hesam","family":"Jahandideh","sequence":"first","affiliation":[{"name":"Department of ENT and Head and Neck Surgery, School of Medicine Firoozgar Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Yadmehr","sequence":"additional","affiliation":[{"name":"ENT and Head and Neck Research Center The Five Senses Health Institute, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Abrishami","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery, Faculty of Dentistry Isf.C, Islamic Azad University  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1242453"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15070309"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2016.04.001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-228666"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.1939"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-025-01804-z"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23502"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1993-7790"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24233"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420939582"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1390011"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.32286"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:22:27Z","timestamp":1784305347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72759"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72759","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.177217589.98946947\/v1","asserted-by":"object"}]},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"2026-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72759"}}