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Here, we describe extramedullary APL causing cauda equina syndrome, underscoring the diagnostic challenges associated with an atypical presentation, highlighting the complexity of distinguishing extramedullary APL from other conditions, and discussing the stepwise approach to diagnosis.<\/jats:p>","DOI":"10.1002\/ccr3.72767","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:38:58Z","timestamp":1780097938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Extramedullary Acute Promyelocytic Leukemia Presenting as Cauda Equina Syndrome: A Rare Case Report and Diagnostic Challenge"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2584-5427","authenticated-orcid":false,"given":"Amir","family":"Ali","sequence":"first","affiliation":[{"name":"University of Southern California Norris Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ringor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kirk Kerkorian School of Medicine at UNLV  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbab","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kirk Kerkorian School of Medicine at UNLV  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Garcia","sequence":"additional","affiliation":[{"name":"Private Practice, Family Medicine Physician  Santa Maria California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravishankar","family":"Konchada","sequence":"additional","affiliation":[{"name":"Radiology St. Rose Dominican Hospitals  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramalingam","family":"Ratnasabapathy","sequence":"additional","affiliation":[{"name":"Medical Oncologist and Hematologist, Horizon Ridge Henderson  Henderson Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3654-0432","authenticated-orcid":false,"given":"Yuna","family":"Chae","sequence":"additional","affiliation":[{"name":"USC Mann School of Pharmacy  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3439-7259","authenticated-orcid":false,"given":"Arman","family":"Melikyan","sequence":"additional","affiliation":[{"name":"USC Mann School of Pharmacy  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Yaghmour","sequence":"additional","affiliation":[{"name":"Internal Medicine, Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases University of Southern California Norris Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msksp.2018.06.002"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.5505\/tjh.2012.94809"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308\u2010017\u20100287\u2010x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.06.028"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199909058422"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5045\/kjh.2011.46.1.52"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288\u2010012\u20100152\u20100"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X20926076"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(22)00106\u20105"},{"key":"e_1_2_13_11_1","volume-title":"Tumor Lysis Syndrome. 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