{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:09Z","timestamp":1786977369408,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hydranencephaly (HE) is a rare congenital condition characterized by near\u2010total absence of the cerebral hemispheres, replaced by cerebrospinal fluid, most commonly resulting from in utero bilateral internal carotid artery occlusion; although maternal alcohol consumption is associated with fetal neurodevelopmental abnormalities, its direct role in HE remains unclear. We report a case of a 42\u2010year\u2010old multiparous woman with chronic alcohol use throughout pregnancy who delivered a female neonate at 40\u2009+\u20095\u2009weeks via spontaneous vaginal delivery. The neonate presented with facial asymmetry and a boggy parietal swelling, while maintaining intact reflexes and normal muscle tone. Third\u2010trimester ultrasonography had suggested hydrocephalus, and postnatal cranial ultrasonography confirmed extensive cerebral destruction with fluid replacing most brain structures. Laboratory investigations, including TORCH screening, were unremarkable. The infant was managed with supportive care and parental counseling. Hydranencephaly is typically associated with early childhood mortality, although rare cases of prolonged survival have been described. Neuroimaging is essential for differentiating HE from severe hydrocephalus and porencephaly, and management remains largely supportive, with ventriculoperitoneal shunting considered in selected cases. This case highlights the importance of early prenatal detection, multidisciplinary management, and increased awareness of potential alcohol\u2010related fetal brain abnormalities to guide counseling and optimize outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.72783","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:28:25Z","timestamp":1779683305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hydranencephaly in Neonate With Prenatal Exposure to Alcohol During Pregnancy"],"prefix":"10.1002","volume":"14","author":[{"given":"Dibya Raj","family":"Chaudhary","sequence":"first","affiliation":[{"name":"BP Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2551-7428","authenticated-orcid":false,"given":"Diwakar","family":"Koirala","sequence":"additional","affiliation":[{"name":"BP Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4839-5116","authenticated-orcid":false,"given":"Samiksha","family":"Lamichhane","sequence":"additional","affiliation":[{"name":"BP Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bivek","family":"Mishra","sequence":"additional","affiliation":[{"name":"BP Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.102015"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3126\/njn.v17i1.28336"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2021.01081"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2013.00014"},{"issue":"12","key":"e_1_2_13_6_1","article-title":"Hydranencephaly in a Newborn: A Case Report and a Review of the Literature","volume":"16","author":"Toumi K.","year":"2024","journal-title":"Cureus"},{"issue":"1","key":"e_1_2_13_7_1","first-page":"41","article-title":"Brain Pathology Following Fetal Vascular Occlusion: An Experimental Study","volume":"8","author":"Myers R. E.","year":"1969","journal-title":"Investigative Ophthalmology"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1986.tb03885.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1973.04160020073014"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198607000-00020"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.13-4-e233"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/90.4.839"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-014-0079-1"},{"issue":"5","key":"e_1_2_13_14_1","first-page":"788","article-title":"Hydranencephaly: Considering Prolonged Survival and Treatment by Endoscopic Choroid Plexus Coagulation","volume":"25","author":"Ray C.","year":"2014","journal-title":"Turkish Neurosurgery"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72783","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:23:05Z","timestamp":1784305385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72783"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72783","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]},"assertion":[{"value":"2025-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72783"}}