{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:05:30Z","timestamp":1784307930247,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hemolacria is a rare condition characterized by bloody tears. Its etiology is often multifactorial, but functional\/psychosomatic mechanisms have been proposed when organic causes are excluded. A 48\u2010year\u2010old woman with a history of multiple traumatic brain injuries (coma in 2008, car accident in 2017) presented with refractory generalized anxiety disorder, major depressive disorder, insomnia disorder, and treatment\u2010resistant hypertension. Since 2022, she developed bilateral hemolacria with a baseline frequency of 4\u20135 episodes daily despite extensive negative ophthalmological, neurological, hematological, and imaging workups. She had been on stable doses of sertraline 100\u2009mg\/day, amlodipine 10\u2009mg\/day, losartan 100\u2009mg\/day, and intermittent zolpidem for at least 6\u2009months. Anodal transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (L\u2010DLPFC; anode F3, cathode Fp2) was administered for 27 sessions over 61\u2009days (1\u20132\u2009mA, 20\u2009min\/session, 5\u2009days\/week). No concurrent medication changes were made during or after the intervention. Marked clinical improvement began around session 12. By session 27, standardized scores showed remission of symptoms (HAM\u2010D\u201017 from 26 to 4, HAM\u2010A from 34 to 6, PSQI from 16 to 5), office blood pressure normalized to 125\u2013135\/80\u201385\u2009mmHg, and hemolacria frequency decreased to one minor episode every 43\u2009days. All improvements were sustained at the 3\u2010month follow\u2010up without further tDCS. This single\u2010case, open\u2010label report describes concurrent reductions in psychiatric, cardiovascular, and hemolacria symptoms that occurred in temporal association with anodal tDCS over the L\u2010DLPFC in a treatment\u2010refractory patient after organic causes had been excluded. Given the uncontrolled design, causality cannot be established; alternative explanations including placebo response, non\u2010specific effects of clinical attention, regression to the mean, or spontaneous remission cannot be excluded. Randomized controlled trials are warranted to investigate the potential efficacy and mechanisms of tDCS in functional hemolacria.<\/jats:p>","DOI":"10.1002\/ccr3.72787","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:48:07Z","timestamp":1779684487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcranial Direct Current Stimulation (\n                    <scp>tDCS<\/scp>\n                    ) for the Treatment of Hemolacria Comorbid With Psychiatric and Somatic Symptoms: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-4831","authenticated-orcid":false,"given":"Roghayeh","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Psychology Payame Noor University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Psychology Payame Noor University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520648"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-022-00359-1"},{"key":"e_1_2_13_4_1","volume-title":"Hemolacria","author":"Tripathy K.","year":"2023"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-1401-2_60-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/25158163241267322"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.198953"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318294c172"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8127"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12050522"},{"key":"e_1_2_13_11_1","first-page":"1119","volume-title":"Neuromodulation (Second Edition)","author":"Gilligan J.","year":"2018"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40846-023-00810-2"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.807151"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2021.05.002"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7712"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-180880"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00371"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72787","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72787","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:23:07Z","timestamp":1784305387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72787"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72787","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]},"assertion":[{"value":"2025-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72787"}}