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Successful treatment and recovery of the facial nerve palsy were achieved through additional surgical debridement and insertion of synthetic calcium sulfate beads as a local antibiotic carrier to the skull base. We describe the characteristics of this novel biodegradable long\u2010term release matrix and the surgical technique in detail. The patient is free from recurrence 2\u2009years postoperatively.<\/jats:p>","DOI":"10.1002\/ccr3.72836","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:11:46Z","timestamp":1780459906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic\u2010Impregnated Calcium Sulfate Beads for Local Therapy of Severe Skull Base Osteomyelitis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-2081","authenticated-orcid":false,"given":"Stefan","family":"Lyutenski","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Helios Hospital Berlin\u2010Buch  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Henze","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Helios Hospital Berlin\u2010Buch  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"James","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Helios Hospital Berlin\u2010Buch  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bloching","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Helios Hospital Berlin\u2010Buch  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196808000-00002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000839"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300202"},{"key":"e_1_2_12_5_1","article-title":"The Risk of Iatrogenic Hypercalcemia in Patients Undergoing Calcium Sulphate Beads Implantation in Prosthetic Joint Surgery: A Systematic Review","volume":"13","author":"Tarar M. 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