{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:05:16Z","timestamp":1784307916860,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Brucellosis is a zoonotic infection that passes to humans from infected animals via direct contact or the intake of raw milk and its products. The hematologic profile most frequently seen in acute brucellosis includes mild anemia and leukopenia. Severe form of thrombocytopenia and multiple wet purpura over the tongue and buccal mucosa are less frequently reported. This article describes a case of a 24\u2010year\u2010old man who presented with an absolute platelet count of 1000\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    \/L; multiple wet purpura over the tongue and buccal mucosa and petechial lesions on the distal shins. The patient was diagnosed with brucellosis according to a positive serologic test and was treated with an antibiotic regimen including ceftriaxone and doxycycline, dexamethasone and a transfusion of 6\u2009units of platelets. Mucocutaneous lesions resolved after 3\u2009days of hospitalization, and platelet counts showed a steady upward trend. Brucella infection may cause severe thrombocytopenia and wet purpura over the tongue and buccal mucosa, which can be reversed with appropriate antimicrobials and steroids.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72838","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:00:58Z","timestamp":1780387258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Thrombocytopenia With Wet Purpura in Brucellosis: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4697-4778","authenticated-orcid":false,"given":"Fatemeh","family":"Ravanbakhsh Ghavghani","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Infectious and Tropical Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Oveisi","family":"Oskouei","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Infectious and Tropical Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3790-9176","authenticated-orcid":false,"given":"Hamed Ebrahimzadeh","family":"Leylabadlo","sequence":"additional","affiliation":[{"name":"Liver and Gastrointestinal Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1571087"},{"key":"e_1_2_13_3_1","first-page":"5","article-title":"Brucellosis: A Highly Infectious Zoonosis of Public Health and Economic Importance","volume":"3","author":"Berhanu G.","year":"2020","journal-title":"Preventive Veterinary Medicine"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008071"},{"issue":"6","key":"e_1_2_13_5_1","first-page":"349","article-title":"A Review of Brucellosis in Iran: Epidemiology, Risk Factors, Diagnosis, Control, and Prevention","volume":"21","author":"Golshani M.","year":"2017","journal-title":"Iranian Biomedical Journal"},{"issue":"3","key":"e_1_2_13_6_1","first-page":"163","article-title":"Analysis of Epidemiological, Clinical, and Laboratory Characteristics of Patients Diagnosed With Brucellosis: A Comprehensive Study","volume":"12","author":"Kili\u00e7 Tekin M.","year":"2024","journal-title":"Namik Kemal Medical Journal"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000612"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7867435"},{"key":"e_1_2_13_9_1","first-page":"2017","article-title":"Wet Purpura: A Sinister Sign in Thrombocytopenia","volume":"1","author":"Mishra K.","year":"2017","journal-title":"BML Case Reports"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2015.1775"},{"key":"e_1_2_13_11_1","first-page":"6","article-title":"Brucellosis\u2010Induced Hemophagocytic Lymphohistiocytosis","volume":"13","author":"Al Noumani J.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idnow.2025.105121"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-5016-y"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.30699\/jambs.28.130.247"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ646"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6608279"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519847406"},{"issue":"7","key":"e_1_2_13_18_1","article-title":"Spontaneous Peritoneal Hemorrhage and Anemia: A Rare Case Report of Immune Thrombocytopenic Purpura","volume":"16","author":"Almeida D. M.","year":"2024","journal-title":"Cureus"},{"issue":"10","key":"e_1_2_13_19_1","article-title":"Immune Thrombocytopenic Purpura and Its Rare Association With a Brucella Infection: A Case Report","volume":"14","author":"Qiu Z.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05466-1"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.5772\/61134"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP50AEEYGREWUZ"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2025.108047"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/318129"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-04829-4"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72838","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:21:18Z","timestamp":1784305278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72838"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72838","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72838"}}