{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:04:44Z","timestamp":1784307884395,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Malignant small round cell tumors are a heterogeneous group of aggressive neoplasms characterized by small, round cell morphology. The undifferentiated cells in these tumors exhibit a high nuclear\u2010cytoplasmic ratio, and definitive histologic diagnosis via light microscopy can be extremely challenging. Diagnostic accuracy significantly improves with immunohistochemistry, molecular analyses, and cytogenetic studies, enhancing diagnosis and treatment, and ultimately leading to better survival rates. Unfortunately, these tests are often not readily available in low and middle\u2010income countries, where childhood cancer rates are highest. We present a case of a male infant who developed a progressive ulcerative mass over a giant congenital melanocytic naevus in the lumbosacral region. Immunohistochemical analysis of the ulcerative mass was positive for Oscar keratin. Despite the high diagnostic uncertainty, the working diagnosis was extra\u2010renal Wilms' Tumor with loco\u2010regional metastasis based on the positive Oscar Keratin. Following the SIOP protocol for Wilms' Tumor management, he underwent neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy. He achieved complete remission with multimodal treatment and is alive 2\u2009years after treatment.<\/jats:p>","DOI":"10.1002\/ccr3.72869","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:18:16Z","timestamp":1780892296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Atypical Presentation, Diagnostic Challenges, and Treatment Response of a Malignant Small Round Cell Tumor in the Lumbo\u2010Inguinal Region of an Infant"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8932-6124","authenticated-orcid":false,"given":"George","family":"Evele","sequence":"first","affiliation":[{"name":"Paediatric Oncology Unit\/Mbingo Baptist Hospital  Mbingo Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouya","family":"Francine","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Unit\/Mbingo Baptist Hospital  Mbingo Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngock","family":"George","sequence":"additional","affiliation":[{"name":"Paediatric Surgery Unit\/Mbingo Baptist Hospital  Mbingo Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bardin","sequence":"additional","affiliation":[{"name":"Pathology Unit\/Mbingo Baptist Hospital  Mbingo Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-326-UTTIBI"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.54861"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30761-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92794-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24321"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/PEDS.2006\u20102315"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0897-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmpo.ijmpo_84_16"},{"key":"e_1_2_12_11_1","first-page":"347","article-title":"Skin Tumors in Childhood","volume":"108","author":"Hamm H.","year":"2011","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139237000.016"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.15586\/codon.wt.2016.ch6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2012.03.005"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72869","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:22:43Z","timestamp":1784305363000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72869"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72869","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72869"}}