{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:09:15Z","timestamp":1792552155471,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T00:00:00Z","timestamp":1688256000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>In patients with sickle cell disease, we must be more cognizant of the possibility of multifocal osteomyelitis. Diagnosis can be challenging in this patient population as the symptoms mimic vaso\u2010occlusive crisis. There is no gold standard in imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Osteomyelitis occurs more frequently in children with sickle cell disease. Diagnosis is challenging as it mimics vaso\u2010occlusive crises, a common manifestation of sickle cell disease. We present a case of a 22\u2010month\u2010old girl with sickle cell disease and multifocal osteomyelitis. We review the literature on the utility of diagnostic imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7288","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T03:48:41Z","timestamp":1688356121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multifocal osteomyelitis in a child with sickle cell disease and review of the literature regarding best diagnostic approach"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-8261","authenticated-orcid":false,"given":"Megan","family":"Scruggs","sequence":"first","affiliation":[{"name":"Department of Pediatrics Rainbow Babies and Children's Hospital  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Pateva","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics Rainbow Babies and Children's Hospital  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2008.545"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28225"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2410-2"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"398","article-title":"Multifocal osteoarticular infection caused by SAlmonella non typhi in a child with sickle cell disease","volume":"20","author":"Caberet B","year":"2013","journal-title":"Arch Pediatr"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2016.04.01"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.10.100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214160"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5334\/jbr-btr.1300"},{"issue":"9","key":"e_1_2_10_10_1","first-page":"1027","article-title":"Diagnosis and management of osteomyelitis","volume":"84","author":"Hatzenbuehler J","year":"2011","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-012-0186-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-020-04735-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4145-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00025-07"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv133.1065"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(99)00137-X"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28517"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T08:37:19Z","timestamp":1692261439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/ccr3.7288"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7288","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2022-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7288"}}