{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:34:01Z","timestamp":1788878041111,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multidrug\u2010resistant tuberculous meningitis (MDR\u2010TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical studies. Here we report a 33\u2010year\u2010old male with MDR\u2010TBM who developed progressive peripheral neuropathy after 6\u2009months of a linezolid\u2010containing regimen. Linezolid was discontinued, but cerebrospinal fluid (CSF) parameters remained abnormal. Contezolid was initiated in July 2023. Within 3\u2009months, the patient's headache and blurred vision resolved; after 5\u2009months of treatment, CSF pressure normalized, protein decreased from 1570 to 501\u2009mg\/L, and glucose returned to normal range. No adverse reactions occurred during contezolid therapy, and clinical improvement was sustained through 24\u2010month follow\u2010up. This case suggests contezolid may be a safe and effective alternative to linezolid for MDR\u2010TBM patients with drug intolerance.<\/jats:p>","DOI":"10.1002\/ccr3.72883","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:19:02Z","timestamp":1781327942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Contezolid in the Treatment of Multidrug\u2010Resistant Tuberculous Meningitis: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Na","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health Medical College of Qingdao University  Qingdao Shandong China"},{"name":"Qingdao Public Health Clinical Center  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health Medical College of Qingdao University  Qingdao Shandong 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