{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:04:45Z","timestamp":1784307885603,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lipomatosis is characterized by abnormal, localized fat overgrowth without associated fat loss. These growths are typically benign and follow specific distribution patterns. When induced by corticosteroids, this fat hypertrophy can occur in various locations, most commonly in the spinal epidural, retro\u2010orbital, and mediastinal spaces. Computed tomography and magnetic resonance imaging are the most effective diagnostic tools. While stopping or reducing corticosteroid therapy can lead to the shrinking or disappearance of these deposits, this outcome is not always consistent. A 52\u2010year\u2010old Black African male from a rural area, with a history of asthma, presented to the Mechare Clinic in Woldia, Ethiopia, reporting two months of intensifying back pain. The patient had been self\u2010managing his symptoms for approximately 15\u2009years using diclofenac, prednisolone, and dexamethasone injections obtained without a medical prescription. Clinical examination revealed characteristic signs of steroid excess, including facial puffiness, a dorsocervical fat pad (buffalo hump), and central obesity (waist circumference of 120\u2009cm). Respiratory assessment showed scattered wheezing and bronchial breath sounds at the left posterior lung base. Diagnostic investigations confirmed leukocytosis, impaired fasting glucose, and vitamin D deficiency. Imaging studies further identified left lower lung consolidation, systemic osteoporosis, multiple rib and vertebral fractures, and diffuse and extensive lipomatosis involving the pleural, pericardial, and mediastinal regions. The therapeutic advantages of corticosteroids must be carefully weighed against the risk of serious side effects. Clinicians should provide close supervision during long\u2010term therapy to ensure that the cumulative risks do not outweigh the clinical benefits. Furthermore, educating patients on the safe and proper use of these medications is essential for minimizing harm.<\/jats:p>","DOI":"10.1002\/ccr3.72966","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:56:07Z","timestamp":1781585767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipomatosis From Prolonged Use of Corticosteroids in Ethiopia: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1166-8566","authenticated-orcid":false,"given":"Habtamu Mesele","family":"Gebray","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Woldia Comprehensive Specialized Hospital  Woldia Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebre Hailu","family":"Dejen","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, College of Health Sciences Woldia University  Woldia Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kindsew Abi","family":"Menge","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Woldia Comprehensive Specialized Hospital  Woldia Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2024.05.003"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(97)82511-8"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojpathology.2011.11001"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06314"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.72019"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.6.704"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2025.104956"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.23563"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S332201"},{"issue":"3","key":"e_1_2_17_11_1","first-page":"107","article-title":"Ignored Complication of Steroids in an Ankylosing Spondylitis Case: Psychotic Depression","volume":"17","author":"Serin S. 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Review of the Literature. Col","volume":"33","author":"Calle F.","year":"2022","journal-title":"Journal de Radiologie"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs052"},{"issue":"4","key":"e_1_2_17_21_1","first-page":"159","article-title":"Nonprescription Corticosteroid Use, Per Capita Consumption and Pattern of Distribution of Commonly Used Corticosteroids in Khuzestan Province Pharmacies Throughout 2016","volume":"8","author":"Dehghan S.","year":"2020","journal-title":"Journal of Pharmaceutical Care"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:20:49Z","timestamp":1784305249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72966"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72966","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72966"}}