{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:04:27Z","timestamp":1784307867807,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Syphilis is a re\u2010emerging global public health concern; recently, its incidence has significantly increased in all demographic groups. However, acute syphilitic posterior placoid chorioretinitis (ASPPC) and syphilitic optic neuropathy in a patient with human immunodeficiency virus (HIV) co\u2010infection are extremely uncommon. ASPPC is a rare ocular infectious condition caused by syphilis that results in potential blindness. Considering that ocular syphilis may present as an initial manifestation, screening for sexually transmitted diseases is warranted. Here, this article presents a successful treatment protocol that resulted in the complete resolution of a case of ASPPC and syphilitic optic neuropathy with HIV co\u2010infection.<\/jats:p>","DOI":"10.1002\/ccr3.72976","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:47:30Z","timestamp":1781588850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Syphilitic Posterior Placoid Chorioretinitis and Syphilitic Optic Neuropathy in a Patient With Human Immunodeficiency Virus Co\u2010Infection"],"prefix":"10.1002","volume":"14","author":[{"given":"Shengsheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Science and Education Training Nanjing Emergency Medical Center  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-7440","authenticated-orcid":false,"given":"Bangtao","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4159"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1901593"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2022.2046791"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcae039"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001302"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-03150-w"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-243923"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002979"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72976","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:20:46Z","timestamp":1784305246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72976"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72976","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72976"}}