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Pericardial tamponade is a rare side effect reported in only very few case reports. Early recognition and therapeutic intervention is vital in all cases. We report a case of a 54\u2010year\u2010old male with Stage 3 lung adenocarcinoma who developed cardiac tamponade secondary to pembrolizumab and subsequently required pericardial window.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.7298","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T06:01:35Z","timestamp":1683007295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pembrolizumab induced pericardial tamponade: A case report"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-5796","authenticated-orcid":false,"given":"Dariusz","family":"Uczkowski","sequence":"first","affiliation":[{"name":"Overlook Medical Center Atlantic Health System Summit New Jersey USA"},{"name":"Morristown Medical Center Atlantic Health System Morristown New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Overlook Medical Center Atlantic Health System Summit New Jersey USA"},{"name":"Morristown Medical Center Atlantic Health System Morristown New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunabh","family":"Sekhri","sequence":"additional","affiliation":[{"name":"Overlook Medical Center Atlantic Health System Summit New Jersey USA"},{"name":"Morristown Medical Center Atlantic Health System Morristown New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbaz","family":"Samad","sequence":"additional","affiliation":[{"name":"Overlook Medical Center Atlantic Health System Summit New Jersey USA"},{"name":"Morristown Medical Center Atlantic Health System Morristown New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls","author":"Flynn JP","year":"2022"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1199310"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28358"},{"key":"e_1_2_11_5_1","unstructured":"U.S. Food and Drug Administration.KEYTRUDA (pembrolizumab) reference ID: 4766009. 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