{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:26:01Z","timestamp":1787120761398,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Hirschsprung's disease is a condition characterized by absence of nerves in the intestines, secondary to failure of migration of neural crest cells therein. Co\u2010occurrence of these conditions is reported previously in a family with a stop mutation in the EDNRB gene. In the present report we present the case of a 26\u2010year\u2010old man who presented with complaints of left facial weakness, episodic generalized headaches, and imbalance. He was previously diagnosed with Hirschsprung's disease and had undergone total colectomy. Subsequent evaluations confirmed MS. Family history was unremarkable, with no family members affected by either condition. Furthermore, we present our experience in managing the case with dimethyl fumarate disease\u2010modifying therapy.<\/jats:p>","DOI":"10.1002\/ccr3.72984","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:05:32Z","timestamp":1783742732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Sclerosis in a Person With Hirschprung's Disease: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Masoud","family":"Etemadifar","sequence":"first","affiliation":[{"name":"Alzahra Research Institute Alzahra University Hospital, Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Shoeib","sequence":"additional","affiliation":[{"name":"Alzahra Research Institute Alzahra University Hospital, Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1675-681X","authenticated-orcid":false,"given":"Mehri","family":"Salari","sequence":"additional","affiliation":[{"name":"Men's Health and Reproductive Health Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2796-6791","authenticated-orcid":false,"given":"Nahad","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Alzahra Research Institute Alzahra University Hospital, Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000622"},{"issue":"8","key":"e_1_2_12_3_1","first-page":"1319","article-title":"Hirschsprung's Disease: Diagnosis and Management","volume":"74","author":"Kessmann J.","year":"2006","journal-title":"American Family Physician"},{"key":"e_1_2_12_4_1","unstructured":"M. E.Lopez \u201cCongenital Aganglionic Megacolon (Hirschsprung Disease) \u201dUpToDate (2026) accessed April 2026 https:\/\/www.uptodate.com\/contents\/congenital\u2010aganglionic\u2010megacolon\u2010hirschsprung\u2010disease."},{"key":"e_1_2_12_5_1","unstructured":"J. P.Wagner S.Shekherdimian andS.Lee \u201cHirschsprung Disease. Medscape \u201d(2026) accessed April 2026 https:\/\/emedicine.medscape.com\/article\/178493."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2025.08.006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028944"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56110611"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.04.026"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028986"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.10.027"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.362"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103449"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13732"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.03.001"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.034"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.08.014"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-019-01427-4"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01588-w"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72984","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:36:20Z","timestamp":1787117780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/ccr3.72984"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72984","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72984"}}